Mismatch Negativity and P3a in Unaffected Siblings of Individuals with Autism Spectrum Disorder and the Exploration on the Neurocognitive Implications.
Evidence suggests different mismatch negativity (MMN) and P3a responses in individuals with autism spectrum disorder (ASD). Since unaffected siblings shared aberrant neurocognition and brain connectivity with ASD probands, this study investigated MMN and P3a responses in unaffected siblings and expl...
| Published in: | Journal of Autism & Developmental Disorders Vol. 56; no. 1; pp. 256 - 269 |
|---|---|
| Main Authors: | , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Jan2026
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191290287&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191290287 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jan2026 vid: 56 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 191290287 179458531 191290287 191290287 10.1007/s10803-024-06520-1 191290287 ppf: 256 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mismatch Negativity and P3a in Unaffected Siblings of Individuals with Autism Spectrum Disorder and the Exploration on the Neurocognitive Implications. aug: au: Chien, Yi-Ling Hsieh, Ming H. Gau, Susan Shur-Fen affil: https://ror.org/03nteze27 Department of Psychiatry, National Taiwan University Hospital and College of Medicine, No.7, Chung-Shan South Road, 10002, Taipei, Taiwan sug: subj: Brain Physiology Siblings Autism Spectrum Disorder Physiopathology Cognition Evaluation Neuropsychology Evaluation Human Male Female Child Adolescence Adult Evoked Potentials, Auditory Attention Memory, Short Term Visual Perception Task Performance and Analysis Electrophysiology Age Factors Intelligence Auditory Perception Phenotype Neuropsychological Tests Neurodevelopment Scales Questionnaires Electroencephalography Descriptive Statistics Data Analysis Software Sex Factors Correlation Coefficient Funding Source Taiwan Cross Sectional Studies Comparative Studies T-Tests Analysis of Covariance Wilcoxon Rank Sum Test Pearson's Correlation Coefficient Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Evidence suggests different mismatch negativity (MMN) and P3a responses in individuals with autism spectrum disorder (ASD). Since unaffected siblings shared aberrant neurocognition and brain connectivity with ASD probands, this study investigated MMN and P3a responses in unaffected siblings and explored its neurocognitive implications and effects modifiers. We assessed 43 unaffected siblings of ASD probands and 64 non-autistic comparisons (NTC) using MMN and P3a on both frequency and duration oddball paradigms. The amplitude and latency of MMN and P3a were compared between unaffected siblings and NTC, and validated in 67 ASD probands. In addition, the neurocognitive correlates of MMN and P3a parameters were explored in attention performance, spatial working memory (SWM), and visual research via the tasks of the Conners' Continuous Performance Test and the Cambridge Neuropsychological Test Automated Battery. Compared to NTC, unaffected siblings and ASD probands presented a shorter MMN latency. The P3a amplitude of the duration paradigm (dP3a) was correlated with fewer commission errors, fewer SWM total errors, higher detectability, and more correct responses on visual search tasks. In addition, the dP3a amplitude significantly interacted with sibship, age, and full-scale IQ to predict attention performance, SWM total errors, and total correct response on visual search. Findings suggest that unaffected siblings of ASD may have earlier brain responses upon novelty discrimination. P3a amplitude may correlate with better neurocognitive performance, but the effect was moderated by sibship, age, and intelligence. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|