Transmethylation and Oxidative Biomarkers in Children with Autism Spectrum Disorder: A Cross Sectional Study.
We aimed to investigate the potential role of biomarkers of transmethylation, oxidative stress, and mitochondrial dysfunction in children with Autism Spectrum Disorder (ASD) by comparing them with that of typically developing children (TDC) controls. We also tried to correlate them with severity of...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 56; no. 1; pp. 269 - 278 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191290301&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191290301 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jan2026 vid: 56 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 191290301 179432212 191290301 191290301 10.1007/s10803-024-06542-9 191290301 ppf: 269 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Transmethylation and Oxidative Biomarkers in Children with Autism Spectrum Disorder: A Cross Sectional Study. aug: au: Gulati, Sheffali Narayan, Chinthana L. Mahesan, Aakash Kamila, Gautam Kapoor, Seema Chaturvedi, Pradeep K. Scaria, Vinod Velpandian, Thirumurthy Jauhari, Prashant Chakrabarty, Biswaroop Datta, Sudip K. R. Pandey, R. M. affil: https://ror.org/02dwcqs71 Centre of Excellence & Advanced Research for Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India sug: subj: Autism Spectrum Disorder Pathology Biological Markers Methionine Metabolism Oxidative Stress Mitochondrial Diseases Human Cross Sectional Studies Descriptive Statistics Data Analysis Software T-Tests Mann-Whitney U Test Post Hoc Analysis Confidence Intervals Odds Ratio Male Female Child, Preschool Child Adolescence Scales Checklists Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: We aimed to investigate the potential role of biomarkers of transmethylation, oxidative stress, and mitochondrial dysfunction in children with Autism Spectrum Disorder (ASD) by comparing them with that of typically developing children (TDC) controls. We also tried to correlate them with severity of autism, sensory issues, behavioural comorbidities and developmental quotients 119 with ASD and 52 age and sex matched typically developing children (TDC) controls were enrolled excluding those with chronic-illness or on any antioxidant therapy/multivitamins/anti-epileptic drugs. Median levels of biomarkers - serum homocysteine, cysteine, methionine, urine uric acid-to-creatinine ratio, arterial lactate, serum vitamin E, vitamin B12, folate, Nε-carboxymethyllysine, Nω- carboxymethylarginine (CMA), dityrosine and MTHFR C677T polymorphism were calculated. Children with ASD were further characterised using Childhood Autism Rating Scale-2, Childhood behavioural checklist, child sensory profile 2 caregiver questionnaire, Developmental Profile 3 for any correlation with the various biomarker levels. The median level of serum homocysteine in ASD group was 9 μmol/L(Range, 7- 16μmol/L), which was significantly higher than controls 7 μmol/L(Range, 4- 11μmol/L)(p=0.01). The prevalence of hyper-homocystinemia(>15μmol/L) was 13.4% in ASD as compared to 3.8% in controls with a significant difference(p=0.04). Dityrosine level was higher among ASD children when compared to TDC (9.8 vs 2.2 counts per second(cps), p<0.001). No significant correlation was found between prevalence of hyperhomocysteinemia and severity of autism/DQ/behavioural issues. No significant difference was found between the median levels of other biomarkers. Results support possible role of transmethylation defects and oxidative stress in ASD pathogenesis. Further studies are warranted for a better understanding of ASD pathogenesis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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