Novel curcumin derivatives as potential anticancer agents: design, synthesis and biological evaluation.
Curcumin, originally isolated as natural product from the rhizome of Curcuma longa L., is widely known for its anticancer properties. However, the clinical application of curcumin is still limited due to its poor absorption and rapid metabolism. In this study, structural modification of curcumin by...
| Publicado en: | Natural Product Research Vol. 40; no. 3; pp. 881 - 891 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191332777&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191332777 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Feb2026 vid: 40 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 191332777 181404045 10.1080/14786419.2024.2429112 191332777 ppf: 881 ppct: 10 formats: tig: atl: Novel curcumin derivatives as potential anticancer agents: design, synthesis and biological evaluation. aug: au: Liu, Wenqing Yang, Sha Pan, Yongchun Wei, Bingliang Liu, Mingsong Zhu, Huajie Xu, Zhidong affil: School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China sug: ab: Curcumin, originally isolated as natural product from the rhizome of Curcuma longa L., is widely known for its anticancer properties. However, the clinical application of curcumin is still limited due to its poor absorption and rapid metabolism. In this study, structural modification of curcumin by introducing active small organic acids into its pyrazole ring intermediate, was employed to yield five curcumin derivatives 5a-5e. All the target compounds were characterised by 1H NMR,13C NMR and ESI-MS. Biological evaluation through the CCK-8 method indicated that nearly all these derivatives displayed higher proliferation inhibitory effect on A549 cells than that of curcumin. Among them, 5d bearing biotin moiety exhibited even stronger cytotoxicity action (2.25 μmol/L) than the positive control drug Doxorubicin (3.99 μmol/L) and therefore became the most promising lead compound for further investigation. Our findings provided a potential approach for the structural optimisation of curcumin derivatization in cancer treatment. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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