Antimicrobial resistance in orthopedics: microbial insights, clinical impact, and the necessity of a multidisciplinary approach—a review.
Antimicrobial resistance (AMR) is rising globally and is a threat and challenge for orthopedic surgery, particularly in managing prosthetic joint infections (PJIs). This review first explores several AMR mechanisms from a microbiological point of view, including selective pressure, horizontal gene t...
| Publicado en: | Acta Orthopaedica Vol. 96; pp. 555 - 569 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Medical Journals Sweden AB
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191461405&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191461405 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17453674 1BVL jtl: Acta Orthopaedica issn: 17453674 maglogo: N pubinfo: dt: 2025 vid: 96 pid: 59195 pub: Medical Journals Sweden AB artinfo: ui: 191461405 191461405 191461405 10.2340/17453674.2025.43477 191461405 ppf: 555 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Antimicrobial resistance in orthopedics: microbial insights, clinical impact, and the necessity of a multidisciplinary approach—a review. aug: au: VAN AGTMAAL, Julia L. VERHEUL, Mariëlle VONKEN, Lieve HELSEN, Kato VARGAS GUERRERO, Marian G. VAN HOOGSTRATEN, Sanne W. G. HURCK, Bianca J. PILLA, Giulia TRINH, Isabell DE BRUIJN, Gert-Jan CALUM, Henrik P. DE BOER, Mark G. J. PIJLS, Bart G. ARTS, Jacobus J. C. affil: Department of Orthopaedic Surgery, Research Institute CAPHRI, Maastricht University Medical Center, Maastricht, the Netherlands;. sug: subj: Orthopedic Surgery Adverse Effects Prosthesis-Related Infections Microbiology Surgical Wound Infection Microbiology Prosthesis-Related Infections Prevention and Control Surgical Wound Infection Prevention and Control Drug Resistance, Microbial Antimicrobial Stewardship Multidisciplinary Care Team Interprofessional Relations One Health Initiative Machine Learning Luminescent Measurements Microscopy Spectrophotometry, Infrared Spectrum Analysis, Raman Antibiotics Therapeutic Use Prosthesis-Related Infections Drug Therapy Surgical Wound Infection Drug Therapy ab: Antimicrobial resistance (AMR) is rising globally and is a threat and challenge for orthopedic surgery, particularly in managing prosthetic joint infections (PJIs). This review first explores several AMR mechanisms from a microbiological point of view, including selective pressure, horizontal gene transfer, and further dissemination. Second, the variation in the rise of AMR across countries is highlighted, including its impact on PJI. While countries with the highest AMR rates are expected to experience the most significant burden, no country will be immune to the increasing prevalence of PJI. Third, this review stresses that multidimensional strategies are needed to combat AMR’s challenges in orthopedic surgery. These include raising awareness across all sectors, including healthcare professionals, the public, healthcare policymakers, and even politicians; advancing diagnostic technologies for early infection detection and classification of resistant or susceptible strains; promoting antibiotic stewardship; and developing new material technologies to prevent or cure PJI. This review highlights the urgent need for a coordinated response from clinicians, researchers, and policymakers to avoid AMR-related complications in PJI cases. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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