Implementation of oral versus intravenous antibiotics in clinical practice at a specialized orthopedic infection unit: a descriptive retrospective cohort study.
Background and purpose — The Oral Versus Intravenous Antibiotics (OVIVA) trial demonstrated that oral antibiotic therapy was noninferior to intravenous antibiotic therapy when used during the initial 6 weeks in the treatment of bone and joint infections (BJIs). We aimed to evaluate clinical outcomes...
| Publicado en: | Acta Orthopaedica Vol. 96; pp. 677 - 684 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Medical Journals Sweden AB
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191461422&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191461422 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17453674 1BVL jtl: Acta Orthopaedica issn: 17453674 maglogo: N pubinfo: dt: 2025 vid: 96 pid: 59195 pub: Medical Journals Sweden AB artinfo: ui: 191461422 191461422 191461422 10.2340/17453674.2025.44571 191461422 ppf: 677 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Implementation of oral versus intravenous antibiotics in clinical practice at a specialized orthopedic infection unit: a descriptive retrospective cohort study. aug: au: BAWER, Robin PETERLIN, Anton A. N. BAK, Jakob GOTTLIEB, Hans affil: Department of Orthopedic Surgery at Copenhagen University Hospital, Herlev Hospital. sug: subj: Antibiotics Administration and Dosage Antibiotics Adverse Effects Administration, Oral Administration, Intravenous Bone Diseases, Infectious Drug Therapy Treatment Outcomes Evaluation Implementation Science Protocols Human Denmark Male Female Academic Medical Centers Descriptive Research Retrospective Design Prospective Studies Electronic Health Records Hematologic Tests Descriptive Statistics Data Analysis Software Comparative Studies Penicillins Therapeutic Use Adverse Drug Event Gastrointestinal Diseases Complications Treatment Failure Reoperation Osteomyelitis Complications Readmission Incidence Middle Age Aged Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background and purpose — The Oral Versus Intravenous Antibiotics (OVIVA) trial demonstrated that oral antibiotic therapy was noninferior to intravenous antibiotic therapy when used during the initial 6 weeks in the treatment of bone and joint infections (BJIs). We aimed to evaluate clinical outcomes, antibiotic treatment details, and complication rates following the implementation of the OVIVA protocol. Methods — All patients treated for BJIs between September 2019 and September 2020 at the specialized orthopedic infection unit of Herlev Hospital were eligible for inclusion. This study included data on patient demographics, antibiotic regimens, type of infection, microbiology, length of stay, adverse drug reactions, and definite treatment failure at 1 year. Results — A cohort of 129 patients was included. After a median of 7 days of intravenous therapy, 127 patients underwent an early switch to oral antibiotics. The most frequently used class of oral antibiotics was penicillins (68%). Adverse drug reactions, mostly gastrointestinal, occurred in 36% of all patients. Definite treatment failure at 1 year was 13% with oral antibiotics. Conclusion — We found a comparably low failure rate of 13% among patients who were able to transition to oral antibiotics when applying the treatment protocol from the OVIVA study. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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