The Neurobiology of Pain, Emotion, and Stress Regulation in Suicide: Role of Cannabinoid, Opioid, Vanilloid, and Galaninergic Systems – A Systematic Review of Postmortem Evidence.
This systematic review investigates the association between the endocannabinoid, vanilloid, opioid, and galaninergic systems and suicide, focusing on post-mortem evidence. Findings indicate increased cannabinoid receptor 1 (CB1) densities in the prefrontal cortex, particularly in individuals with al...
| Published in: | International Journal of Mental Health & Addiction Vol. 24; no. 1; pp. 529 - 565 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Case Study |
| Published: |
Springer Nature
Feb2026
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=191498571&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 191498571 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 15571874 46AW jtl: International Journal of Mental Health & Addiction issn: 15571874 maglogo: N pubinfo: dt: Feb2026 vid: 24 iid: 1 pid: 237 pub: Springer Nature artinfo: ui: 191498571 10.1007/s11469-024-01419-5 ppf: 529 ppct: 36 formats: fmt: – @attributes: type: T – @attributes: type: P size: 1.5MB tig: atl: The Neurobiology of Pain, Emotion, and Stress Regulation in Suicide: Role of Cannabinoid, Opioid, Vanilloid, and Galaninergic Systems – A Systematic Review of Postmortem Evidence. aug: au: Escelsior, Andrea Guglielmo, Riccardo Zizzi, Alessio Fioravanti, Margherita Sanvi, James Arduino, Gabriele Servetti, Martina Colaci, Francesco da Silva, Beatriz Pereira Nozza, Paolo Pompili, Maurizio Amore, Mario Serafini, Gianluca affil: https://ror.org/0107c5v14 Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Ospedale Policlinico San Martino, Genoa, Italy https://ror.org/04d7es448 IRCCS Ospedale Policlinico San Martino, Genova, Italy https://ror.org/042t93s57 Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132, Genova, Italy https://ror.org/0107c5v14 Department of Experimental Medicine, University of Genova, Viale Benedetto XV 3, 16132, Genova, Italy https://ror.org/02mgzgr95 Istituto delle Scienze Neurologiche di Bologna, 40139, Bologna, Italy https://ror.org/04d7es448 Pathology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy https://ror.org/02be6w209 Department of Neurosciences, Mental Health and Sensory Organs, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189, Rome, Italy su: Suicide Suffering Emotions Cannabinoids Stress management Neurobiology Opioids TRPV cation channels sug: subj: Suicide Suffering Emotions Cannabinoids Stress management Neurobiology Opioids TRPV cation channels keyword: Endocannabinoid system Galaninergic system Medical and Health Sciences Clinical Sciences Opioid system Post-mortem evidence Vanilloid system Endocannabinoid system Galaninergic system Medical and Health Sciences Clinical Sciences Opioid system Post-mortem evidence Vanilloid system ab: This systematic review investigates the association between the endocannabinoid, vanilloid, opioid, and galaninergic systems and suicide, focusing on post-mortem evidence. Findings indicate increased cannabinoid receptor 1 (CB1) densities in the prefrontal cortex, particularly in individuals with alcohol use disorder and mood disorders who died by suicide. Conversely, a decrease in CB1 receptors was observed in individuals with schizophrenia treated with antipsychotics, suggesting that this reduction may be more closely related to underlying psychopathology than directly to suicidal behavior. Limited evidence on the vanilloid system suggests stress-related alterations could influence suicide, warranting further exploration. Similarly, the opioid and galaninergic systems show alterations in individuals who died by suicide, with increased mu-opioid receptor (MOR) expression possibly representing an adaptive response to altered endogenous peptide levels. The review underscores the need for more extensive research to clarify the roles of these biological pathways in suicide, advocating for studies comparing individuals who died by suicide with and without psychiatric disorders to non-psychiatric controls to advance our understanding of these complex interactions and their implications. pubtype: Academic Journal doctype: Case Study src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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