Investigating Predictive Factors of Pathological Complete Response After Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer.
Background: Standard treatment for locally advanced rectal cancer (LARC) includes neoadjuvant chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. Although achieving a pathological complete response (pCR) is considered a favorable prognostic factor, the parameters influencing pCR r...
| Publicado en: | International Journal of Cancer Management Vol. 18; no. 1; pp. 1 - 8 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Medical Journals Commission of the Ministry of Health & Medical Education
Jan-Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191502730&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191502730 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25384422 L6AI jtl: International Journal of Cancer Management issn: 25384422 maglogo: N pubinfo: dt: Jan-Dec2025 vid: 18 iid: 1 pid: 66482 pub: Medical Journals Commission of the Ministry of Health & Medical Education artinfo: ui: 191502730 191502730 191502730 10.5812/ijcm-159417 191502730 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Investigating Predictive Factors of Pathological Complete Response After Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer. aug: au: Rakhsha, Afshin Khandani, Maryam Kalantari Shokri, Fateme affil: Cancer Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Rectal Neoplasms Pathology Rectal Neoplasms Radiotherapy Cancer Patients Psychosocial Factors Neoadjuvant Therapy Pathologic Complete Response Predictive Value of Tests Treatment Outcomes Evaluation Human Male Female Academic Medical Centers Cross Sectional Studies Quantitative Studies Analytic Research Retrospective Design Chi Square Test T-Tests Fisher's Exact Test Neoplasm Staging Chemoradiotherapy Male Female ab: Background: Standard treatment for locally advanced rectal cancer (LARC) includes neoadjuvant chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. Although achieving a pathological complete response (pCR) is considered a favorable prognostic factor, the parameters influencing pCR remain incompletely defined. Objectives: This study investigated predictive factors for achieving pCR in patients with LARC who underwent neoadjuvant CRT. Methods: This retrospective cross-sectional study included 100 patients with LARC who underwent neoadjuvant CRT between May 2018 and September 2023 at Shohadaye Tajrish Hospital, Tehran, Iran. Patients' demographics, clinicopathological data, and treatment details, including chemotherapy and radiotherapy data, were reviewed to analyze their correlation with pCR. Statistical analysis was performed using the chi-square test, Student's t-test, and Fisher's exact test to assess factors associated with pCR. A P-value of < 0.05 was considered statistically significant. Results: Pathological complete response was obtained in 28% of the cases. Clinical stage and induction chemotherapy were independent predictors of pCR (P < 0.05). Patients with T3N1 and T3N2 stages had higher pCR rates, whereas none of the T4N2 patients achieved pCR. The number of induction chemotherapy cycles was strongly associated with pCR. The pCR rates were significantly higher for those patients who received four cycles or more (P < 0.05). No significant association was found between pCR and age, gender, Body Mass Index (BMI), tumor differentiation, or radiotherapy dosimetry. Conclusions: The clinical stage at diagnosis and the extent of induction chemotherapy were significant predictors of pCR in this study. Further prospective studies are warranted to validate these findings and explore additional predictive factors. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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