Enhancing Tomotherapy for Brain Tumors: A Noncoplanar Technique with Improved Dosimetric Outcomes.
Background: Tomotherapy, as a radiotherapy technique, is limited by its inability to deliver noncoplanar beams, which are often critical for isodose conformity. Objectives: The presnt study introduces a head base plate that allows pitch and yaw adjustments to facilitate noncoplanar radiation deliver...
| Publicado en: | International Journal of Cancer Management Vol. 18; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Medical Journals Commission of the Ministry of Health & Medical Education
Jan-Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191502751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191502751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25384422 L6AI jtl: International Journal of Cancer Management issn: 25384422 maglogo: N pubinfo: dt: Jan-Dec2025 vid: 18 iid: 1 pid: 66482 pub: Medical Journals Commission of the Ministry of Health & Medical Education artinfo: ui: 191502751 191502751 191502751 10.5812/ijcm-162491 191502751 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Enhancing Tomotherapy for Brain Tumors: A Noncoplanar Technique with Improved Dosimetric Outcomes. aug: au: Siavashpour, Zahra Ehzari, Mohadeseh Bagher Aghamiri, Seyed Mahmoud Reza Houshyari, Mohammad Arbabi, Kourosh Majidi, Shima Kalantari, Faraz affil: Department of Radiotherapy Oncology, Shohada-e Tajrish Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Brain Neoplasms Radiotherapy Radiotherapy, Conformal Radiation Dosage Dosimetry Treatment Outcomes Iran Experimental Studies Phantoms, Imaging Brain Radiography Tomography, X-Ray Computed Comparative Studies Paired T-Tests Descriptive Statistics Data Analysis Software Radiotherapy, Computer-Assisted Optic Nerve Radiation Effects Lens, Crystalline Radiation Effects Eye Radiation Effects ab: Background: Tomotherapy, as a radiotherapy technique, is limited by its inability to deliver noncoplanar beams, which are often critical for isodose conformity. Objectives: The presnt study introduces a head base plate that allows pitch and yaw adjustments to facilitate noncoplanar radiation delivery with improved dosimetric outcomes. Methods: A custom-designed head base plate was developed and integrated into a standard tomotherapy system to allow controlled noncoplanar beam delivery. A phantom study was conducted to compare dosimetric outcomes between coplanar and noncoplanar techniques for a pseudo-hypophysis tumor. Key dosimetric parameters, including dose distribution and dosevolume metrics for target and organs at risk (OARs), were evaluated. Results: Noncoplanar tomotherapy demonstrated improved dose conformity and homogeneity, with a superior dose-volume ratio (90% - 110%) compared to the coplanar approach. Significant reductions in OARs doses were observed, particularly in the eyes and optic nerves, ranging from 2.2 to 3.9 Gy. These enhancements were achieved without compromising target coverage or increasing low-dose spread. Conclusions: The noncoplanar technique, facilitated by the proposed head base plate, offers significant dosimetric benefits, enhancing the safety and efficacy of tomotherapy for brain tumors. This innovation addresses a key limitation of tomotherapy systems and holds potential for broader clinical applications. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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