Efficacy and Tolerability of Methotrexate for Idiopathic Granulomatous Mastitis: A Systematic Review and Meta‐Analysis.
Background: Idiopathic granulomatous mastitis (IGM) is a challenging inflammatory breast disease with limited standardized treatment guidelines. Methods: This meta‐analysis systematically evaluated the efficacy and safety of methotrexate (MTX) in IGM, pooling data from observational studies. We asse...
| Publicado en: | Breast Journal Vol. 2026; pp. 1 - 14 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2/13/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191576483&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191576483 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: 2/13/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 191576483 191576483 191576483 10.1155/tbj/6710172 191576483 ppf: 1 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Efficacy and Tolerability of Methotrexate for Idiopathic Granulomatous Mastitis: A Systematic Review and Meta‐Analysis. aug: au: Han, Ying Shi, LiHui Zhang, YanRan Wani, Imtiaz affil: Department of Science and Education,, Tongzhou Maternal and Child Health Hospital of Beijing,, Beijing, 101100,, China sug: subj: Mastitis Drug Therapy Granuloma Drug Therapy Methotrexate Therapeutic Use Drug Efficacy Evaluation Patient Safety Evaluation Drug Tolerance Evaluation Pathologic Complete Response Evaluation Recurrence Risk Factors Methotrexate Adverse Effects Treatment Termination Risk Assessment Human Funding Source Systematic Review Meta Analysis Female Adolescence Adult Middle Age Descriptive Statistics Confidence Intervals Inferential Statistics Drug Therapy, Combination PubMed Embase Cochrane Library Checklists Data Analysis Software Turkiye Iran Iraq China United States Linear Regression Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female ab: Background: Idiopathic granulomatous mastitis (IGM) is a challenging inflammatory breast disease with limited standardized treatment guidelines. Methods: This meta‐analysis systematically evaluated the efficacy and safety of methotrexate (MTX) in IGM, pooling data from observational studies. We assessed complete remission rates, recurrence rates, and severe side effects leading to MTX discontinuation using both common and random effects models, accounting for heterogeneity. Results: Nine studies were included. In analyses without control groups, the pooled complete response rate for MTX was 61.6% (95% CI: 40.4–79.2%), with significant heterogeneity (I2 = 81.4%). Combination therapy showed a higher complete response rate in the common effect model (78.0%, 95% CI: 71.4–83.3%) compared to monotherapy (46.6%, 95% CI: 34.2–59.3%), though this difference was not significant in the random effects model. The overall pooled proportion of severe side effects leading to MTX discontinuation was low at 1.23% (95% CI: 0.40–3.74%) in the common effect model and 0.51% (95% CI: 0.03–9.37%) in the random effects model, with no significant heterogeneity. In controlled studies, MTX showed no significant difference in complete remission compared to steroid‐containing controls. Conclusion: Based on a pooled complete response rate of 61.6%, MTX appears to be an effective and well‐tolerated treatment for IGM, though substantial heterogeneity exists in uncontrolled studies. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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