Willingness to Participate in Deprescribing Trials: A Survey of Older Adults in Two Countries.
Background: This study investigates the willingness of older adults to participate in a hypothetical deprescribing clinical trial. Methods: We conducted an online survey of adults aged 65+ years in Australia and the United States. Participants rated their willingness to enroll in a deprescribing tri...
| Publicado en: | Journal of the American Geriatrics Society Vol. 74; no. 2; pp. 500 - 509 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Feb2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=191631201&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 191631201 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00028614 20Q jtl: Journal of the American Geriatrics Society issn: 00028614 maglogo: Y pubinfo: dt: Feb2026 vid: 74 iid: 2 pid: 480 pub: Wiley-Blackwell artinfo: ui: 191631201 10.1111/jgs.70186 ppf: 500 ppct: 9 formats: tig: atl: Willingness to Participate in Deprescribing Trials: A Survey of Older Adults in Two Countries. aug: au: Vordenberg, Sarah E. Dulo, Noelia Chaitoff, Alexander Ingwersen, Kirsten Weir, Kristie Rebecca affil: Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor Michigan,, USA University of Michigan Center for Bioethics and Social Sciences in Medicine, Ann Arbor Michigan,, USA University of Michigan School of Public Health, Ann Arbor Michigan,, USA Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor Michigan,, USA Sydney Health Literacy Lab, Sydney School of Public, Faculty of Medicine and Health, University of Sydney, Sydney, Australia Leeder Centre for Health Policy, Economics, and Data, Sydney School of Public, Faculty of Medicine and Health, University of Sydney, Sydney, Australia Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland su: Australia United States Health literacy Health status indicators Clinical trials Human research subjects Content analysis Sex distribution Quantitative research Age distribution Population geography Trust Patient participation Educational attainment Scale analysis (Psychology) Research funding Questionnaires Multiple regression analysis Deprescribing Descriptive statistics Chi-squared test Thematic analysis Odds ratio Intention Statistics Confidence intervals sug: subj: Health literacy Health status indicators Clinical trials Human research subjects Content analysis Sex distribution Quantitative research Age distribution Population geography Trust Patient participation Educational attainment Australia United States Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) Scale analysis (Psychology) Research funding Questionnaires Multiple regression analysis Deprescribing Descriptive statistics Chi-squared test Thematic analysis Odds ratio Intention Statistics Confidence intervals keyword: content analysis decline deprescribe preferences survey content analysis decline deprescribe preferences survey ab: Background: This study investigates the willingness of older adults to participate in a hypothetical deprescribing clinical trial. Methods: We conducted an online survey of adults aged 65+ years in Australia and the United States. Participants rated their willingness to enroll in a deprescribing trial, responding to the statement, "Research is conducted to assess the safety and effectiveness of stopping medicines. Imagine your doctor made you aware of a research trial aiming to help people stop one or more of their medicines. To what extent would you be willing to enroll in the study?" on a 6‐point Likert scale with "Not at all willing (1)" and "Extremely willing (6)" as the scale anchors. Participants provided a brief free‐text explanation. We dichotomized the outcome variable as willing (scores 4–6) and unwilling (scores 1–3) to enroll and conducted descriptive analyses, chi‐square tests, and univariate and multivariate logistic regression models. Free‐text responses were analyzed using content analysis, with descriptive statistics summarizing themes. Results: There were 2334 participants in the quantitative analysis and 2237 participants in the content analysis. Most were willing (n = 1705, 73%) rather than unwilling (n = 629, 27%) to enroll in a deprescribing trial (p < 0.001, 95% CI 0.712, 0.748). Over one‐half of participants (n = 1252, 56%) expressed the "positive about deprescribing trials" domain, with Australian participants more likely to do so (AU 666 [60%] vs. US 586 [52%], p < 0.001). Participants (n = 1047, 47%) frequently reported at least one theme of the "concerns and hesitations" domain (n = 669, 30%) with US participants more frequently expressing negative views (US 273 [24%] vs. AU 211 [19%], p = 0.002) and reporting the "mistrust" theme (US 74 [7%] vs. AU 35 [3%], p < 0.001). Conclusions: Older adults showed a willingness to engage in deprescribing trials, though concerns may affect enrollment. Clear communication of risks and benefits could support recruitment. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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