Physical Activity Modifies the Association between C-Reactive Protein -Triglyceride - Glucose Index (CTI) and Dyslipidemia: Evidence from a 10-Year Chinese Cohort.
Dyslipidemia is a major contributor to cardiovascular disease. The C-reactive protein - triglyceride - glucose index (CTI), which reflects insulin resistance and systemic inflammation, has increasingly been recognized as a potential marker for metabolic disturbances. However, its predictive value fo...
| Publicado en: | Journal of Sports Science & Medicine Vol. 25; no. 1; pp. 112 - 130 |
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| Autores principales: | , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Hakan Gur, Journal of Sports Science & Medicine
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191636986&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191636986 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13032968 FYN jtl: Journal of Sports Science & Medicine issn: 13032968 maglogo: N pubinfo: dt: Mar2026 vid: 25 iid: 1 pid: 26030 pub: Hakan Gur, Journal of Sports Science & Medicine artinfo: ui: 191636986 191636986 191636986 10.52082/jssm.2026.112 191636986 ppf: 112 ppct: 18 formats: fmt: @attributes: type: P tig: atl: Physical Activity Modifies the Association between C-Reactive Protein -Triglyceride - Glucose Index (CTI) and Dyslipidemia: Evidence from a 10-Year Chinese Cohort. aug: au: Wang, Yang Luo, Zixuan Zhou, Zihan Zhang, Xiaoquan affil: Faculty of Physical Culture, Tomsk State University, Tomsk, Russian Federation sug: subj: Hyperlipidemia Risk Factors C-Reactive Protein Blood Triglycerides Blood Blood Glucose Biological Markers Blood Risk Assessment Physical Activity In Middle Age Physical Activity In Old Age Funding Source China Human Male Female Middle Age Aged Prospective Studies Questionnaires Exercise Intensity Plasma Preprocedural Fasting Confidence Intervals Descriptive Statistics Age Factors Incidence Probability Sample Structured Questionnaires One-Way Analysis of Variance Kruskal-Wallis Test Chi Square Test Cox Proportional Hazards Model Kaplan-Meier Estimator Log-Rank Test Logistic Regression Data Analysis Software Chronic Disease Epidemiology Prevalence Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Dyslipidemia is a major contributor to cardiovascular disease. The C-reactive protein - triglyceride - glucose index (CTI), which reflects insulin resistance and systemic inflammation, has increasingly been recognized as a potential marker for metabolic disturbances. However, its predictive value for incident dyslipidemia remains uncertain, and the role of physical activity in this association requires further clarification. This study pro-spectively examined the association between CTI and the risk of dyslipidemia, and further assessed whether physical activity modifies this relationship in middle-aged and older Chinese adults. A total of 7,954 participants aged ≥45 years without dyslipidemia at baseline were enrolled, using data from the China Health and Retirement Longitudinal Study (2011 - 2020). Physical activity was assessed using the CHARLS physical activity questionnaire, which captures the frequency and duration of vigorous, moderate, and light activities. Based on the frequency and duration of these activities, participants were categorized into low, moderate, and high physical activity groups. CTI was derived from high-sensitivity C-reactive protein, fasting plasma glucose, and triglyceride levels. Incident dyslipidemia was defined based on abnormal lipid profiles, ongoing lipid-lowering treatment, or a physician's clinical diagnosis. Cox proportional hazards regression with restricted cubic splines was applied to evaluate associations, with stratified analyses by sex, age, and physical activity level. During 10 years of follow-up, 2,011 new cases of dyslipidemia were recorded. Each 1-unit increase in CTI corresponded to approximately a 9% higher risk of dyslipidemia (HR = 1.09, 95% CI: 1.01 - 1.18). Individuals in the highest CTI quartile had a 15% greater risk compared with those in the lowest quartile (HR = 1.15, 95% CI: 1.01 - 1.30). Stronger associations were observed in men (HR = 1.20, 95% CI: 1.05 - 1.36) and adults aged 45 - 59 years (HR = 1.22, 95% CI: 1.08 - 1.39), whereas no significant effect was found in women. When stratified by physical activity, a 1-unit CTI increase was linked to about a 10% higher risk in the light and moderate activity groups, and to a 28% higher risk in the vigorous activity group, with risk plateauing at higher CTI levels. Elevated CTI was prospectively associated with an increased risk of dyslipidemia, particularly in men and individuals in midlife. Physical activity appeared to influence this relationship, suggesting that CTI could serve as a practical marker for early risk stratification. These findings underscore the importance of regular exercise in preventing dyslipidemia. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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