Neuromelanin, iron and MRI measurements in midbrain tissues of Parkinson's and Alzheimer's subjects.
Background: In Parkinson's disease, decreased neuromelanin and increased Fe concentrations derive from the loss of neuromelanin-containing neurons in the substantia nigra, which is spared in Alzheimer's disease. We aimed to measure neuromelanin and Fe concentrations in post mortem midbrain subregion...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 10 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191664430&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191664430 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2026 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 191664430 191664430 191664430 10.3389/fnagi.2026.1672578 191664430 ppf: 1 ppct: 9 formats: tig: atl: Neuromelanin, iron and MRI measurements in midbrain tissues of Parkinson's and Alzheimer's subjects. aug: au: Zucca, Fabio A. Cassidy, Clifford M. Sturini, Michela Tuominen, Lauri Adorni, Fulvio Cheung, Victoria Casella, Luigi Sulzer, David Pezzoli, Gianni Isaias, Ioannis U. Horga, Guillermo Zecca, Luigi affil: Institute of Biomedical Technologies, National Research Council of Italy, Segrate, Italy sug: subj: Melanins Parkinson Disease Alzheimer's Disease Brain Anatomy and Histology Magnetic Resonance Imaging Human New York Funding Source New York Experimental Studies Specimen Handling Descriptive Statistics Data Analysis Software Confidence Intervals Predictive Value of Tests ab: Background: In Parkinson's disease, decreased neuromelanin and increased Fe concentrations derive from the loss of neuromelanin-containing neurons in the substantia nigra, which is spared in Alzheimer's disease. We aimed to measure neuromelanin and Fe concentrations in post mortem midbrain subregions of patients with Parkinson's and Alzheimer's disease, and to investigate their effect on MRI signals. Methods: We imaged neuromelanin in brain slices of Parkinson's (N = 4) and Alzheimer's disease (N = 7) subjects using neuromelanin-sensitive MRI sequences, compared the results with neuromelanin and Fe concentrations in the same sections, and calculated imaging maps for each subject. Results: Both neuromelanin and Fe concentrations provided unique contributions to neuromelanin-MRI. Compared to Alzheimer's disease, subjects with Parkinson's disease exhibited increased neuromelanin-MRI values in the superior colliculus and periaqueductal gray matter, and higher Fe concentration in the substantia nigra. Conclusion: Results support the use of neuromelanin-MRI to study neuromelanin and Fe in substantia nigra and neighboring regions for investigating patients with Parkinson's disease and other movement disorders. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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