From single-cell snapshots to spatial panoramas – a holistic multiomics map of glioblastoma.
Single-cell studies have replaced bulk TCGA "subtypes" with a dynamic model in which multiple malignant programs interconvert in glioblastoma, and the balance among these programs is shaped by genetic lesions and local ecological cues. These programmes mirror distorted developmental gene programmes,...
| Publicado en: | Visualized Cancer Medicine Vol. 6; pp. 1 - 11 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
EDP Sciences
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191728812&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191728812 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 27404218 MY5N jtl: Visualized Cancer Medicine issn: 27404218 maglogo: N pubinfo: dt: 2025 vid: 6 pid: 76090 pub: EDP Sciences artinfo: ui: 191728812 191728812 191728812 10.1051/vcm/2025015 191728812 ppf: 1 ppct: 10 formats: tig: atl: From single-cell snapshots to spatial panoramas – a holistic multiomics map of glioblastoma. aug: au: Yan, Rui Song, Xiaowei Hu, Yishan Wang, Yi Lv, Yanju Jiang, Kaiteng Li, Li Hu, Yizhou affil: Department of Oncology, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, China sug: subj: Glioma Physiopathology Multiomics Genomics Transcriptomes Gene Expression Profiling Hypoxia, Brain Neoplastic Processes RNA Analysis Sequence Analysis Epidermal Growth Factor Receptors Cytokines Proteomics Mass Spectrometry Glial Cells Macrophages ab: Single-cell studies have replaced bulk TCGA "subtypes" with a dynamic model in which multiple malignant programs interconvert in glioblastoma, and the balance among these programs is shaped by genetic lesions and local ecological cues. These programmes mirror distorted developmental gene programmes, and their intrinsic developmental plasticity fuels state switching and therapeutic escape. Spatial multi-omics now anchors these programs to anatomy, revealing a reproducible, hypoxia-graded five-layer architecture from necrotic core to infiltrative rim and identifying hypoxia as a long-range organizer. Whole-tumour 3D sampling links clonal evolution to territory, showing that early driver events can span the lesion, while later changes remain regionally restricted. This geography-aware view helps explain why single agents often fail and points to niche-targeted combinations and delivery strategies tailored to the blood-tumour barrier states. We outline how an integrated, spatially resolved multi-omics atlas can guide compartment-specific therapy and prospective monitoring in precision neuro-oncology. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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