Protocol for Safety, Feasibility, and Efficacy of Using Targeted Transcutaneous Spinal Cord Stimulation to Treat Hypotension During Acute Inpatient Rehabilitation in Individuals With SCI.
Transcutaneous spinal cord stimulation (tSCS) has shown evidence of leveraging intact neural circuits to increase blood pressure (BP) in hypotensive people with chronic spinal cord injury (SCI). The primary aim is to determine the safety and feasibility of using tSCS to promote seated systolic BP (S...
| Publicado en: | Topics in Spinal Cord Injury Rehabilitation Vol. 32; no. 1; pp. 12 - 21 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | protocol tables/charts Journal Article |
| Publicado: |
KnowledgeWorks Global, Ltd
Winter2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191766934&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191766934 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10820744 0OF jtl: Topics in Spinal Cord Injury Rehabilitation issn: 10820744 maglogo: N pubinfo: dt: Winter2026 vid: 32 iid: 1 pid: 81084 pub: KnowledgeWorks Global, Ltd place: Richmond, Virginia artinfo: ui: 191766934 191766934 191766934 10.46292/sci25-00028 191766934 ppf: 12 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Protocol for Safety, Feasibility, and Efficacy of Using Targeted Transcutaneous Spinal Cord Stimulation to Treat Hypotension During Acute Inpatient Rehabilitation in Individuals With SCI. aug: au: Chavez, Jorge Curtis, Genevieve L. Weir, Joseph P. Tsai, Chung-Ying Fox, Finn E. Harel, Noam Y. Murray, Lynda M. Goldsmith, Jacob A. Sutor, Thomas W. Huang, Vincent Escalon, Miguel X. Bryce, Thomas N. Wecht, Jill M. affil: Spinal Cord Damage Research Center, James J Peters VA Medical Center, Bronx, New York sug: subj: Hospitalization Spinal Cord Injuries Rehabilitation Hypotension, Orthostatic Therapy Spinal Cord Stimulation Methods Patient Safety Evaluation Treatment Outcomes Randomized Controlled Trials Prospective Studies ab: Transcutaneous spinal cord stimulation (tSCS) has shown evidence of leveraging intact neural circuits to increase blood pressure (BP) in hypotensive people with chronic spinal cord injury (SCI). The primary aim is to determine the safety and feasibility of using tSCS to promote seated systolic BP (SBP) within a target range of 110-130 mm Hg and to mitigate the fall in BP with transition to an upright position in hypotensive participants during acute inpatient rehabilitation (AIR) following SCI. Cathode placement on the spine will be randomized among 4 sites: T7/8, T9/10, T11/12, and L1/2. Mapping for other stimulation parameters includes waveform (monophasic, biphasic, pseudo-monophasic), frequency (30, 60, 120 Hz), use of a carrier frequency (0, 10 kHz), and stimulation amplitude (0-100 mA). Each mapping session will consist of 2 sit-up tests, one without stimulation followed by one with stimulation. During the sit-up test with stimulation, intensity will be slowly increased to 30 mA with continuous monitoring of BP, heart rate, pain, and symptoms of orthostatic hypotension (OH) and autonomic dysreflexia (AD). Once 30 mA is reached, brachial BP will be monitored for 5 minutes. If below the target SBP range, stimulation intensity will be increased in increments of 5 to 10 mA until one of the following occurs: (1) SBP is within the target range, (2) stimulation is intolerable, (3) 100 mA is reached, or (4) stimulation is delivered for 30 minutes. Safety and feasibility will be measured by assessing burn frequency, pain level, and symptoms of AD and OH along with scheduling compliance. pubtype: Academic Journal doctype: protocol tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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