Comparative Analysis of Atherosclerotic Changes in the Carotid Artery: A Cross-sectional Study of Hemodialysis Versus Peritoneal Dialysis Patients.
Background: Carotid artery atherosclerosis tends to progress more rapidly among dialysis-dependent patients; however, the contribution of selected dialysis modality — specifically hemodialysis (HD) versus peritoneal dialysis (PD) — has yielded inconsistent findings in the literature. Objectives: Thi...
| Publicado en: | International Cardiovascular Research Journal Vol. 19; no. 1; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Brieflands
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191800957&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191800957 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22519130 FBPD jtl: International Cardiovascular Research Journal issn: 22519130 maglogo: N pubinfo: dt: Dec2025 vid: 19 iid: 1 pid: 69510 pub: Brieflands place: , <Blank> artinfo: ui: 191800957 191800957 191800957 10.69107/icrj-167557 191800957 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparative Analysis of Atherosclerotic Changes in the Carotid Artery: A Cross-sectional Study of Hemodialysis Versus Peritoneal Dialysis Patients. aug: au: Jahromi, Mahsa Torabi Hooshmandi, Sedigheh Imani, Mohammad Hossein Doroudi, Fatemeh Kheirandish, Nasim Shafiee, Maryam Saem, Amirhossein Jamshidi, Saideh Drissi, Hamed Bazrafshan affil: Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran sug: subj: Atherosclerosis Diagnosis Dialysis Patients Hemodialysis Adverse Effects Peritoneal Dialysis Adverse Effects Carotid Arteries Pathology Calcinosis Carotid Stenosis Carotid Intima-Media Thickness Lipids Blood Human Male Female Dialysis Centers Iran Academic Medical Centers Comparative Studies Cross Sectional Studies Ultrasonography, Carotid Arteries Biochemical Phenomena Diagnosis, Laboratory Mann-Whitney U Test Multivariate Analysis Logistic Regression Linear Regression Univariate Statistics Prevalence Lipoproteins, HDL Cholesterol Blood Lipoproteins, LDL Cholesterol Male Female ab: Background: Carotid artery atherosclerosis tends to progress more rapidly among dialysis-dependent patients; however, the contribution of selected dialysis modality — specifically hemodialysis (HD) versus peritoneal dialysis (PD) — has yielded inconsistent findings in the literature. Objectives: This study seeks to analyze carotid artery calcification (CAC), stenosis, and intima-media thickness (CIMT) using Doppler ultrasound, as well as newly emerged atherogenic indices in patients undergoing regular HD versus PD. Methods: A comparative cross-sectional study design was utilized, involving thirty-two randomly selected patients undergoing either HD or PD (16 HD and 16 PD), conducted from January to May 2024 at dialysis centers associated with Shiraz University of Medical Sciences in Iran. Data were analyzed using IBM SPSS Statistics (version 27) employing Mann-Whitney U, Fisher's exact test, and regression models. Results: Four atherogenic indices were evaluated, namely the total cholesterol to high-density lipoprotein (HDL)-C ratio, low-density lipoprotein (LDL)-C to HDL-C ratio, Lipoprotein Combined Index, and remnant cholesterol. Notably, all indices were significantly elevated among PD patients (P = 0.002, 0.020, 0.001, and 0.008, respectively). Conversely, CAC was more common in HD patients, especially in the right carotid artery (50% vs. 12.5%, P = 0.027). Additionally, carotid artery stenosis was exclusively identified among HD patients (31.3%, P = 0.022). No significant disparities were found in average CIMT or the CIMT measurements of the right or left carotid arteries across the groups. These findings remained consistent regardless of age, gender, underlying causes of kidney failure, and serum biochemistry, particularly serum calcium, phosphorus, vitamin D, and parathyroid hormone (PTH) levels. Conclusions: Patients undergoing HD had worse structural carotid disease, while patients undergoing PD had a worse atherogenic lipid profile. These disparities between modalities make it even more important to have personalized cardiovascular risk assessment and monitoring plans. Additionally, the limitations of CIMT suggest the need for integration with more sensitive imaging modalities to better evaluate medial calcification, thereby informing clinical decision-making and personalized care strategies for end-stage kidney disease patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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