Multifocal Osteonecrosis in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Syndrome Associated With Pyoderma Gangrenosum and Other Complications: A Case Report.
Systemic lupus erythematosus (SLE) is a quintessential illustration of an autoimmune disease. It results from complex interactions that include impaired apoptotic clearance, increased activity of both the innate and adaptive immune systems, complement activation, the development of immune complexes,...
| Published in: | Case Reports in Medicine Vol. 2026; pp. 1 - 7 |
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| Main Authors: | , , , |
| Format: | case study diagnostic images pictorial tables/charts Journal Article |
| Published: |
Wiley-Blackwell
2/23/2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191804006&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191804006 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16879627 902N jtl: Case Reports in Medicine issn: 16879627 maglogo: N pubinfo: dt: 2/23/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 191804006 191804006 191804006 10.1155/carm/7107020 191804006 ppf: 1 ppct: 6 formats: tig: atl: Multifocal Osteonecrosis in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Syndrome Associated With Pyoderma Gangrenosum and Other Complications: A Case Report. aug: au: Adib, Ehsan Banaei, Shokofeh Enteshari-Moghaddam, Afsaneh Nandi, Semonti affil: Students Research Committee,, School of Medicine,, Ardabil University of Medical Sciences,, Ardabil, Iran, arums.ac.ir sug: subj: Osteonecrosis Diagnosis Osteonecrosis Drug Therapy Lupus Erythematosus, Systemic Drug Therapy Antiphospholipid Syndrome Drug Therapy Pyoderma Gangrenosum Drug Therapy Wound Care Methods Osteonecrosis Etiology Adult Female Lupus Erythematosus, Systemic Complications Antiphospholipid Syndrome Complications Pyoderma Gangrenosum Etiology Leg Ulcer Recurrence Drug Tapering Prednisolone Administration and Dosage Folic Acid Administration and Dosage Aspirin Administration and Dosage Spironolactone Administration and Dosage Warfarin Administration and Dosage Dexamethasone Administration and Dosage Medication Compliance Wound Infection Microbiology Wound Infection Drug Therapy Antibiotics Administration and Dosage Antibodies Blood Treatment Outcomes Adult: 19-44 years Female ab: Systemic lupus erythematosus (SLE) is a quintessential illustration of an autoimmune disease. It results from complex interactions that include impaired apoptotic clearance, increased activity of both the innate and adaptive immune systems, complement activation, the development of immune complexes, and ensuing tissue inflammation, which collectively contribute to a sustained autoimmune response. We present a case relating to a 37‐year‐old female patient (from Ardabil, Iran) who received a diagnosis of SLE and antiphospholipid syndrome (APS), in accordance with established diagnostic criteria. She is currently admitted to the hospital due to a recurring pyoderma gangrenosum ulcer, accompanied by pain and swelling in her left leg. The patient tested positive for ANA, lupus anticoagulant, anti–beta2‐glycoprotein I (anti–beta2GPI), and anti‐Ro antibodies. These results, along with her clinical manifestations such as spontaneous abortion, stroke, malar rash, photosensitivity, and pyoderma gangrenosum ulcers, confirm a diagnosis of SLE associated with APS according to the relevant criteria. After appropriate medical treatment, she was identified as experiencing a lupus flare and multifocal osteonecrosis in the knee, hip, and shoulder. pubtype: Academic Journal doctype: case study diagnostic images pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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