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Common bile duct dilatation on MRI in autosomal dominant polycystic kidney disease.

Purpose: Polycystic liver disease is the most prevalent extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). Non-obstructive asymptomatic common bile duct (CBD) dilatation has been observed anecdotally on CT scans, but CT is not optimal for biliary visualization. Here, w...

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Published in:Abdominal Radiology Vol. 51; no. 2; pp. 758 - 768
Main Authors: Sattar, Usama, Zhu, Chenglin, Yin, Xiaorui, Luo, Xianfu, Bazojoo, Vahid, Prince, Albert S., Rennert, Hanna, Brandman, Danielle, Schonfeld, Emily, Blumenfeld, Jon D., Prince, Martin R.
Format: Journal Article
Published: Springer Nature Feb2026
Online Access:View this record in EBSCOhost
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      dt: Feb2026
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00261-025-05122-4
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        atl: Common bile duct dilatation on MRI in autosomal dominant polycystic kidney disease.
      aug:
        au:
          Sattar, Usama
          Zhu, Chenglin
          Yin, Xiaorui
          Luo, Xianfu
          Bazojoo, Vahid
          Prince, Albert S.
          Rennert, Hanna
          Brandman, Danielle
          Schonfeld, Emily
          Blumenfeld, Jon D.
          Prince, Martin R.
        affil: https://ror.org/02r109517 Weill Cornell Medicine, New York, USA
      sug:
      ab: Purpose: Polycystic liver disease is the most prevalent extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). Non-obstructive asymptomatic common bile duct (CBD) dilatation has been observed anecdotally on CT scans, but CT is not optimal for biliary visualization. Here, we measured CBD diameter on T2-weighted MRI in ADPKD subjects to determine if CBD dilatation is associated with ADPKD. Methods: CBD diameter was measured retrospectively on ADPKD subjects (n = 254) and on age- and sex-matched controls without ADPKD (n = 254) who underwent abdominal MRI. CBD diameter in these groups was compared and correlated with clinical, laboratory and magnetic resonance imaging (MRI) features, including organ volumes and cyst burden. Results: CBD median diameter [interquartile range, IQR, 25%, 75%] was 22% larger in ADPKD compared to controls (5.6 [4.7, 6.9] mm vs. 4.6 [3.9, 5.4] mm, p < 0.001). CBD diameter measurements had excellent inter-observer agreement (Intraclass correlation coefficient = 0.92). Thirteen (5.1%) ADPKD subjects had a CBD diameter ≥ 10 mm compared to 1 (0.4%) control subject (p < 0.001). Multivariable analysis found the presence of PKD1 or PKD2 mutation (beta = 1.5, P < 0.001) and age (beta = 0.04, p < 0.001) to be associated with increased CBD diameter and serum albumin associated with decreased CBD diameter (beta=-0.39, p < 0.001). Conclusion: ADPKD subjects had 22% larger CBD diameters than in non-ADPKD controls and were more likely to have CBD dilatation ≥ 10 mm without CBD obstruction. Awareness of this association of non-obstructive CBD dilatation with ADPKD may limit unnecessary diagnostic testing.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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