Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy.
Alterations of the microbiome-gut-brain (MGB) axis have been associated with autism spectrum disorder (ASD) and disorders of gut-brain interaction (DGBI). DGBI are highly prevalent in autistic children and are associated with worsening behaviour and anxiety. Treatments such as probiotics, prebiotics...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 56; no. 3; pp. 1027 - 1046 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191886344&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191886344 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Mar2026 vid: 56 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 191886344 180315886 180723409 191886344 191886344 10.1007/s10803-024-06588-9 191886344 ppf: 1027 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy. aug: au: Mitchell, Leanne K. Heussler, Helen S. Burgess, Christopher J. Rehman, Ateequr Steinert, Robert E. Davies, Peter S.W. affil: https://ror.org/00rqy9422 Child Health Research Centre, Faculty of Medicine, The University of Queensland, South Brisbane, QLD, Australia sug: subj: Gastrointestinal Diseases Drug Therapy Child Behavior Anxiety Drug Therapy Autism Spectrum Disorder In Infancy and Childhood Synbiotics Administration and Dosage Hypnosis Gut Microbiota Treatment Outcomes Human Male Female Child, Preschool Child Adolescence Randomized Controlled Trials Random Assignment Pilot Studies Prospective Studies Bifidobacterium Brain Physiology Checklists Questionnaires Sequence Analysis Exploratory Research Australia Social Media DSM Anxiety Prevention and Control Stress, Psychological Prevention and Control Descriptive Statistics Comparative Studies Data Analysis Software Two-Way Analysis of Variance T-Tests Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: Alterations of the microbiome-gut-brain (MGB) axis have been associated with autism spectrum disorder (ASD) and disorders of gut-brain interaction (DGBI). DGBI are highly prevalent in autistic children and are associated with worsening behaviour and anxiety. Treatments such as probiotics, prebiotics and gut-directed hypnotherapy (GDH) have shown efficacy in improving gut symptoms in children. The primary objective of the study was to compare changes in gastrointestinal (GI) scores following a 12-week intervention of synbiotics (prebiotic + probiotic) +/- GDH with a follow-up at 24 weeks. Secondary objectives included changes in behavioural and anxiety symptoms, while changes in gut microbiome composition were assessed as an exploratory objective. Children diagnosed with ASD aged 5.00-10.99 years (n = 40) were recruited and randomised (1:1) to a 12-week intervention of either synbiotics (SYN group) or synbiotics + GDH (COM group). Both the SYN and COM group experienced significant reductions in total GI scores post-intervention and at follow-up (p < 0.001), with no superiority of the COM treatment over the SYN treatment. The COM group showed beneficial reductions in anxiety scores (p = 0.002) and irritability behaviours (p < 0.001) which were not present in the SYN group. At follow-up, only those in the COM group maintained significant reductions in GI pain scores (p < 0.001). There were significant changes in gut microbiota such as increases in Bifidobacterium animalis and Dialister in both groups over time. In conclusion, synbiotics with or without GDH may help support standard care for autistic children who suffer comorbid DGBI. The trial was prospectively registered at clinicialtrials.gov on 16 November 2020 (NCTO4639141). pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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