Gray Matter Volume Correlates of Co-Occurring Depression in Autism Spectrum Disorder.
Autism Spectrum Disorder (ASD) involves neurodevelopmental syndromes with significant deficits in communication, motor behaviors, emotional and social comprehension. Often, individuals with ASD exhibit co-occurring depression characterized by a change in mood and diminished interest in previously en...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 56; no. 3; pp. 1003 - 1017 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191886350&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191886350 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Mar2026 vid: 56 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 191886350 180420312 191886350 191886350 10.1007/s10803-024-06602-0 191886350 ppf: 1003 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Gray Matter Volume Correlates of Co-Occurring Depression in Autism Spectrum Disorder. aug: au: Dhar, Dolcy Chaturvedi, Manasi Sehwag, Saanvi Malhotra, Chehak Udit Saraf, Chetan Chakrabarty, Mrinmoy affil: https://ror.org/03vfp4g33 Department of Social Sciences and Humanities, Indraprastha Institute of Information Technology Delhi, 110020, New Delhi, India sug: subj: Gray Matter Physiology Depression Autism Spectrum Disorder Comorbidity Human Funding Source Male Female Adolescence Adult Cross Sectional Studies Multiple Linear Regression Post Hoc Analysis T-Tests Descriptive Statistics Chi Square Test Brain Pathology Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Autism Spectrum Disorder (ASD) involves neurodevelopmental syndromes with significant deficits in communication, motor behaviors, emotional and social comprehension. Often, individuals with ASD exhibit co-occurring depression characterized by a change in mood and diminished interest in previously enjoyable activities. Due to communicative challenges and a lack of appropriate assessments in this cohort, co-occurring depression can often go undiagnosed during routine clinical examinations and, thus, its management neglected. The literature on co-occurring depression in adults with ASD is limited. Therefore, understanding the neural basis of the co-occurring psychopathology of depression in ASD is crucial for identifying brain-based markers for its timely and effective management. Using structural MRI and phenotypic data from the Autism Brain Imaging Data Exchange (ABIDE II) repository, we examined the pattern of relationship regional grey matter volume (rGMV) has with co-occurring depression and autism severity within regions of a priori interest in adults with ASD (n = 44; age = 17–28 years). Further, we performed an exploratory analysis of the rGMV differences between ASD and matched typically developed (TD, n = 39; age = 18–31 years) samples. The severity of co-occurring depression correlated negatively with the rGMV of the right thalamus. Additionally, a significant interaction was evident between the severity of co-occurring depression and core ASD symptoms towards explaining the rGMV in the left cerebellum crus II. The results further the understanding of the neurobiological underpinnings of co-occurring depression in adults with ASD towards exploring neuroimaging-based biomarkers in the same cohort. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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