Dose Modification factors (DMF) Evaluation in MammoSite Breast Brachytherapy Using Monte Carlo Simulation.
Background & Objective: Partial Breast Irradiation (PBI) targets the tissue surrounding the tumor in breast cancer brachytherapy. Dose distribution can be affected by the type of radiation source, tumor depth, which alters backscatter, and by the concentration of contrast agents used for imaging. Th...
| Publicado en: | Journal of Advances in Medical & Biomedical Research Vol. 33; no. 161; pp. 307 - 315 |
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| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Zanjan University of Medical Sciences & Health Services
Nov/Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191904496&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191904496 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26766264 N5MJ jtl: Journal of Advances in Medical & Biomedical Research issn: 26766264 maglogo: N pubinfo: dt: Nov/Dec2025 vid: 33 iid: 161 pid: 65276 pub: Zanjan University of Medical Sciences & Health Services artinfo: ui: 191904496 191904496 191904496 10.30699/jambr.33.161.307 191904496 ppf: 307 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Dose Modification factors (DMF) Evaluation in MammoSite Breast Brachytherapy Using Monte Carlo Simulation. aug: au: Samadani, Atefeh Shamsaei, Mojtaba Mousavi Zarandi, Ali affil: Department of Energy Engineering and Physics, Amirkabir University, Tehran, Iran. sug: subj: Brachytherapy Equipment and Supplies Breast Radiation Effects Simulations Radiation Dosage Breast Neoplasms Physiopathology Breast Neoplasms Radiotherapy Radiotherapy, Computer-Assisted Methods Scattering, Radiation Descriptive Statistics Data Analysis Software Equipment Design Models, Biological Radiometry Catheters Iodine Models, Statistical Contrast Media Diagnostic Use ab: Background & Objective: Partial Breast Irradiation (PBI) targets the tissue surrounding the tumor in breast cancer brachytherapy. Dose distribution can be affected by the type of radiation source, tumor depth, which alters backscatter, and by the concentration of contrast agents used for imaging. These factors may modify the dose delivered to the targeted area. Both 192Ir and 60Co sources are commonly used in PBI, and understanding how these factors interact is essential for accurate dose delivery and treatment optimization. Dose modification factors (DMFs) can be used to quantify these effects. The objective of this study is to evaluate the effect of tissue heterogeneity on the dose delivered to the 1-cm tumor margin and to calculate a dose modification factor relative to a homogeneous model. Materials & Methods: Monte Carlo simulations were performed using a 30 cm water-equivalent spherical phantom and a 4 cm diameter MammoSite balloon applicator. HDR 60Co and 192Ir sources were placed inside the balloon. DMF was defined as the ratio of the dose rate at 1 cm from the balloon surface under full-scatter conditions to the dose rate when a limited tissue thickness existed beyond the prescription point. Tissue thicknesses ranged from 0 to 10 cm, and contrast agent concentrations varied from 0% to 25%. Results: Dose reductions of approximately 5% for 192Ir and 1% for 60Co were observed when no tissue was present beyond the prescription depth. At 25% contrast concentration, 192Ir showed an additional 4% reduction, while the dose reduction for 60Co remained below 0.5% across all contrast levels. Conclusion: The study emphasizes the importance of accounting for backscatter loss and contrast-induced attenuation, particularly for 192Ir, to prevent underdosing. Applying DMF is essential for accurate treatment planning in surface-adjacent breast tumors undergoing MammoSite brachytherapy. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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