Prevalent Types of Peristomal Skin Damage During Chemoradiotherapy and Their Risk Factors.

Significance: Colorectal cancer is currently ranked third in terms of the global cancer incidence. Enterostomy, a common surgical procedure for colorectal cancer treatment, creates a temporary or permanent stoma in the abdominal wall for waste excretion. Cancer itself and the associated treatments,...

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Published in:Advances in Wound Care (2162-1918) Vol. 15; no. 3; pp. 181 - 191
Main Authors: Chen, Yi, Lu, Yan, Zhang, LiJuan, Li, LaiJuan
Format: pictorial review tables/charts Journal Article
Published: Mary Ann Liebert, Inc. Mar2026
Online Access:View this record in EBSCOhost
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      dt: Mar2026
      vid: 15
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      pub: Mary Ann Liebert, Inc.
      place: New Rochelle, New York
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        191984272
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        10.1089/wound.2023.0215
        191984272
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        atl: Prevalent Types of Peristomal Skin Damage During Chemoradiotherapy and Their Risk Factors.
      aug:
        au:
          Chen, Yi
          Lu, Yan
          Zhang, LiJuan
          Li, LaiJuan
        affil: School of Nursing, Fudan University, Shanghai, China.
      sug:
        subj:
          Peristomal Skin Care
          Chemoradiotherapy Adverse Effects
          Risk Assessment
          Colorectal Neoplasms Radiotherapy
          Ostomy Care
          Radiodermatitis Etiology
          Colorectal Neoplasms Surgery
          Radiotherapy Adverse Effects
          Wound Healing
          Radiodermatitis Classification
          Dermatitis, Contact
          Radiodermatitis Epidemiology
          Ileostomy
          Radiodermatitis Diagnosis
          Acneiform Eruptions Risk Factors
          Fistula
          Enterostomy Adverse Effects
          Pyoderma Gangrenosum Risk Factors
          Wound Care
      ab: Significance: Colorectal cancer is currently ranked third in terms of the global cancer incidence. Enterostomy, a common surgical procedure for colorectal cancer treatment, creates a temporary or permanent stoma in the abdominal wall for waste excretion. Cancer itself and the associated treatments, such as chemotherapy and radiation therapy, increase the likelihood of various types of peristomal skin damage. Recent Advances: Recent research has focused on developing more targeted treatment approaches for peristomal moisture-associated skin damage (P-MASD). In addition, studies are investigating the potential of novel wound care products and therapies to enhance healing and reduce the risk of complications. There is also growing interest in understanding the different types except P-MASD during chemoradiotherapy. Different types match the varied treatments. Thus, we aimed to comprehensively review the most prevalent types of peristomal skin damage during chemoradiotherapy and their associated risk factors. Critical Issues: The five prevalent types of peristomal skin damage that occur during chemoradiotherapy are peristomal radiodermatitis, P-MASD, peristomal acneiform rash, peristomal pyoderma gangrenosum, and peristomal abscess/infection/fistula. The risk factors vary depending on the type; however, they include the radiation dose, ileostomy surgery, chemoradiotherapy-associated diarrhea, use of epidermal growth factor receptor inhibitors, inflammatory bowel disease, and unclear factors. Future Directions: This review guides the clinical identification of peristomal skin damage during chemoradiotherapy, laying a solid foundation for developing effective strategies to prevent this condition.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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