Relationship Between Trimethoprim‐Sulfamethoxazole‐Induced Hepatotoxicity and Cytochrome Protein 450 2C9 Using Food and Drug Administration Adverse Event Reporting System Database.

Background: Trimethoprim‐sulfamethoxazole (TMP‐SMX) is the second most frequently implicated drug for liver injury. A previous study reported that its onset may be due to the activation of cytochrome protein 450 (CYP) 2C9. However, few studies have measured the expression levels of CYP2C9 in clinica...

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Bibliographic Details
Published in:Journal of Clinical Pharmacy & Therapeutics Vol. 2026; pp. 1 - 8
Main Authors: Kato, Hideo, Shiraishi, Chihiro, Hagihara, Mao, Mikamo, Hiroshige, Iwamoto, Takuya, Imran, Ali
Format: research tables/charts Journal Article
Published: Wiley-Blackwell 3/3/2026
Online Access:View this record in EBSCOhost