Cognitive performance and lifetime occupational exposures in a regional Australian population: a distributed lag mixtures approach.
Examination of exposures over a lifetime of employment and work-related disease has largely focused on the effects of single agents. In reality, workers are exposed to mixtures of agents. In a community cohort of 1621 older participants (Hunter Community Study) with a mean age of 68.0 years (SD 6.8...
| Publicado en: | International Journal of Environmental Health Research Vol. 36; no. 3; pp. 357 - 369 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192005974&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192005974 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Mar2026 vid: 36 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 192005974 185961454 192005974 192005974 10.1080/09603123.2025.2520897 192005974 ppf: 357 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cognitive performance and lifetime occupational exposures in a regional Australian population: a distributed lag mixtures approach. aug: au: Knott, Peter G Nolan, Erin Oldmeadow, Christopher Attia, John Schofield, Peter W Benke, Geza McEvoy, Mark affil: School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia sug: subj: Occupational Exposure Adverse Effects Cognition Evaluation Aging Human Australia Male Female Middle Age Aged Aged, 80 and Over Prospective Studies Retrospective Design Record Review Data Analysis Software Descriptive Statistics Bivariate Statistics Sensitivity and Specificity Occupational Diseases Employment Clinical Assessment Tools Funding Source Confidence Intervals Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Examination of exposures over a lifetime of employment and work-related disease has largely focused on the effects of single agents. In reality, workers are exposed to mixtures of agents. In a community cohort of 1621 older participants (Hunter Community Study) with a mean age of 68.0 years (SD 6.8 yr), cognitive performance was assessed using the Audio Recorded Cognitive Screen, and lifetime occupational histories used to retrospectively estimate yearly exposures to a range of chemicals from the Finnish job-exposure matrix. This study utilised Bayesian Kernel Machine Regression – Distributed Lag Models to investigate potential time windows of increased susceptibility to cognitive effects following retirement. Furthermore, the research explored exposure-response relationships between multiple chemicals, with adjustments for covariates identified from a directed acyclic graph. Analysis identified a window of susceptibility from welding fume exposures 17 years after commencement of work at age 18. The negative effects from lead (Pb) at levels below current exposure standards were identified. Bivariate interactions from co-exposure of carbon monoxide to lead, toluene and trichloroethylene were identified, the magnitude of which may not be statistically meaningful. This study identified effects on cognition post-retirement associated with occupational exposures to a mixture of chemicals encountered throughout the participants' working life. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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