Association between pesticide exposure and colorectal cancer risk: a systematic review and meta-analysis.
Colorectal cancer (CRC) is a leading global malignancy, yet the relationship between pesticide exposure and CRC risk remains controversial. This systematic review and meta-analysis evaluates the association between exposure to specific pesticide classes (fumigants, fungicides, herbicides, and insect...
| Published in: | International Journal of Environmental Health Research Vol. 36; no. 3; pp. 425 - 452 |
|---|---|
| Main Authors: | , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
Mar2026
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192005979&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192005979 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Mar2026 vid: 36 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 192005979 186358435 192005979 192005979 10.1080/09603123.2025.2527318 192005979 ppf: 425 ppct: 27 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between pesticide exposure and colorectal cancer risk: a systematic review and meta-analysis. aug: au: Moosavy, Seyedhamid Darmadi, Darmadi Fakhri, Yadolah Masoud Hosseini, Sayed Yumashev, Alexey affil: Associate professor of gastroenterology and hepatology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran sug: subj: Environmental Exposure Adverse Effects Pesticides Adverse Effects Colorectal Neoplasms Risk Factors Colonic Neoplasms Risk Factors Rectal Neoplasms Risk Factors Risk Assessment Human Male Female Systematic Review Meta Analysis PubMed Embase Descriptive Statistics Data Analysis Software Odds Ratio Confidence Intervals Carcinogens Herbicides Insecticides Checklists Male Female ab: Colorectal cancer (CRC) is a leading global malignancy, yet the relationship between pesticide exposure and CRC risk remains controversial. This systematic review and meta-analysis evaluates the association between exposure to specific pesticide classes (fumigants, fungicides, herbicides, and insecticides) and the risk of colon, colorectal, and rectal cancers. A comprehensive search of international databases (Scopus, PubMed, Web of Science, Embase) was conducted up to January 2025. Adjusted risk estimates were pooled using a fixed-effect model for CRC outcomes. Analysis of 32 studies revealed no significant associations between fumigants and CRC risk [colon: ES = 0.87, 95% CI (0.57–1.17); colorectal: ES = 0.92, 95% CI (0.67–1.17); rectal: ES = 1.04, 95% CI (0.54–1.54)]. Similarly, fungicides showed no significant associations [colon: ES = 0.83, 95% CI (0.62–1.03); colorectal: ES = 0.89, 95% CI (0.72–1.07); rectal: ES = 0.96, 95% CI (0.62–1.31)]. Herbicides also demonstrated no risk associations across CRC [colon: ES = 0.98, 95% CI (0.85–1.10); colorectal: ES = 0.98, 95% CI (0.85–1.10); rectal: ES = 0.98, 95% CI (0.85–1.10)]. However, insecticide exposure was associated with a reduced risk of colon cancer (ES = 0.85, 95% CI: 0.80–0.91), though no significant links were observed for colorectal or rectal cancers. No association was observed between exposure to fumigants, fungicides, or herbicides and the risk of CRC. Insecticides may confer a modest protective effect against colon cancer, though further mechanistic and epidemiological studies are warranted. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|