Patient characteristics' moderation of multinutrients treatment response in school-age children with attention deficit hyperactivity disorder.
Objective: This study analyzed data from the Micronutrients for ADHD in Youth (MADDY) 8-week RCT to identify moderators of treatment response to multinutrients, i.e., patient characteristics likely to predict optimal benefit based on the Clinical Global Impression-Improvement (CGI-I)- scale. Methods...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 35; no. 2; pp. 427 - 436 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192008937&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192008937 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Feb2026 vid: 35 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 192008937 187591765 192008937 192008937 10.1007/s00787-025-02851-1 192008937 ppf: 427 ppct: 9 formats: tig: atl: Patient characteristics' moderation of multinutrients treatment response in school-age children with attention deficit hyperactivity disorder. aug: au: Leung, Brenda MY Feng, Cindy Roy, Anupam Liu, Yang S. Johnstone, Jeanette M. Hatsu, Irene E. Arnold, L. Eugene affil: https://ror.org/044j76961 Faculty of Health Sciences, University of Lethbridge, 4401, Lethbridge, AB, Canada sug: subj: Attention Deficit Hyperactivity Disorder Diet Therapy Treatment Outcomes Micronutrients Dietary Supplements Human Secondary Analysis Funding Source Child Descriptive Statistics Male Female Confidence Intervals Bivariate Statistics Data Analysis Software Parents Educational Status Child: 6-12 years Male Female ab: Objective: This study analyzed data from the Micronutrients for ADHD in Youth (MADDY) 8-week RCT to identify moderators of treatment response to multinutrients, i.e., patient characteristics likely to predict optimal benefit based on the Clinical Global Impression-Improvement (CGI-I)- scale. Methods: Classification tree analysis investigated demographic and clinical history variables as potential moderators of treatment response. Effect sizes (ES) with confidence intervals (CI) were generated using bivariate analysis of risk difference of proportions derived from the classification tree between-treatment effects stratified by the moderator variable. Results: The classification tree showed a higher response rate among multinutrient–treated children (n = 70) with university-educated parents compared to those with parents with less than a university education (64% vs. 36%); a finding also supported by the bivariate analysis (ES = 0.35, 95% CI = 0.03–0.67). Within university-educated parents, a larger percentage of children with past ADHD medication use were responders compared to no past ADHD medication use (83% vs. 52%). Classification tree also revealed that among multinutrient-treated children with university-educated parents without past ADHD medication, higher baseline CGI-Severity score was responders compared to lower baseline score (67% vs. 33%). Bivariate analysis predicted higher response in participants whose parents reported alcohol use disorder (ES = 0.43, 95% CI = 0.10–0.76), or illegal drug use (ES = 0.68, 95% CI = 0.52–0.84), or learning problems (ES = 0.44, 95% CI = 0.13–0.75). Conclusions: Parent education level, substance use disorder or learning problems, and child's previous medication use moderated multinutrient response in children with ADHD. These findings have implications for future research and clinical practice. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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