Disseminated cryptococcosis in an HIV patient with hepatitis C as the associated risk factor.

Background and Purpose: In the context of HIV/AIDS, cryptococcosis emerges as one of the most common opportunistic infections, with a predilection for affecting individuals with compromised immune function. Case report: This study aimed to present a compelling case of disseminated cryptococcosis in...

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Publicado en:Current Medical Mycology Vol. 11; pp. 1 - 5
Autores principales: Dhawan, Pallavi, Gupta, Varsha, Gupta, Monica, Gupta, Parakriti, Singla, Nidhi
Formato: case study pictorial tables/charts Journal Article
Publicado: Mazandaran University of Medical Sciences 2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2025
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      pub: Mazandaran University of Medical Sciences
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        10.22034/cmm.2025.345248.1600
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        atl: Disseminated cryptococcosis in an HIV patient with hepatitis C as the associated risk factor.
      aug:
        au:
          Dhawan, Pallavi
          Gupta, Varsha
          Gupta, Monica
          Gupta, Parakriti
          Singla, Nidhi
        affil: Department of Microbiology, Government Medical College Hospital, Chandigarh, India
      sug:
        subj:
          Cryptococcosis Diagnosis
          Cryptococcosis Risk Factors
          Hepatitis C Complications
          HIV Infections Complications
          HIV-Positive Persons Psychosocial Factors
          Risk Assessment
          Cryptococcus
          Male
          Adult
          Abdominal Pain Etiology
          Diarrhea Etiology
          Fever Etiology
          Abdomen Ultrasonography
          Splenomegaly Ultrasonography
          Hepatomegaly Ultrasonography
          Substance Abuse
          Persons Who Use Intravenous Drugs
          Coinfection
          Spinal Puncture
          Blood Culture
          Cerebrospinal Fluid Analysis
          Mass Spectrometry
          Fungemia
          Antifungal Agents Therapeutic Use
          Blood-Brain Barrier
          Neuroinflammation
          Treatment Outcomes
          Immunocompromised Host
          Diagnosis, Differential
          Multidisciplinary Care Team
          Adult: 19-44 years
          Male
      ab: Background and Purpose: In the context of HIV/AIDS, cryptococcosis emerges as one of the most common opportunistic infections, with a predilection for affecting individuals with compromised immune function. Case report: This study aimed to present a compelling case of disseminated cryptococcosis in a 29-year-old male with a complex medical history, marked by HIV infection, hepatitis C, and a longstanding history of intravenous drug abuse. Blood sample of the patient as well as the cerebrospinal fluid sample grew Cryptococcus neoformans. Immunochromatographic test performed on CSF and serum sample was also positive. Conclusion: Chronic Hepatitis C Virus can disrupt the blood-brain barrier and cause neuroinflammation predisposing the central nervous system to hematogenous seeding during fungemia. Multifaceted medical background of the patient underscored the challenges in the management of comorbidities.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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