Effects of Body Position on Respiratory Pressure and Muscle Activity in Amyotrophic Lateral Sclerosis and Healthy Subjects.
Background: Amyotrophic lateral sclerosis (ALS) is a fatal heterogeneous neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons and spinal cord. Measurement of respiratory muscle strength has been shown to be an important assessment in the decision-making p...
| Publicado en: | Respiratory Care Vol. 71; no. 3; pp. 307 - 315 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192043758&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192043758 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Mar2026 vid: 71 iid: 3 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 192043758 192043758 192043758 10.1177/19433654251389828 192043758 ppf: 307 ppct: 8 formats: tig: atl: Effects of Body Position on Respiratory Pressure and Muscle Activity in Amyotrophic Lateral Sclerosis and Healthy Subjects. aug: au: Maciel, Ana Cristina de Medeiros Garcia da Silva, Ana Aline Marcelino Medeiros da Fonseca, Jéssica Danielle Vieira, Rayane Grayce da Silva da Silva, Lailane Saturnino Lima, Thiago Bezerra Wanderley e Pondofe, Karen de Medeiros Otto-Yáñez, Matías Torres-Castro, Rodrigo Vera-Uribe, Roberto Vilaró, Jordi Dourado Junior, Mario Emilio Teixeira Resqueti, Vanessa Regiane Fregonezi, Guilherme Augusto de Freitas affil: Ms. Maciel, Ms. da Silva, Dr. da Fonseca, Ms. da Silva Vieira, Ms. da Silva, Ms. Lima, Dr. Pondofe, Dr. Resqueti, and Dr. Fregonezi are affiliated with the Pneumocardiovascular Lab/HUOL and the Laboratório de Inovação Tecnológica em Reabilitação, Departamento de Fisioterapia, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. sug: subj: Amyotrophic Lateral Sclerosis Physiopathology Respiratory Muscles Physiopathology Muscle Strength Evaluation Body Positions Peak Expiratory Flow Rate Methods Human Case Control Studies Spirometry Electromyography Respiratory Function Tests Functional Assessment Data Analysis Software Descriptive Statistics Wilcoxon Rank Sum Test Paired T-Tests Funding Source ab: Background: Amyotrophic lateral sclerosis (ALS) is a fatal heterogeneous neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons and spinal cord. Measurement of respiratory muscle strength has been shown to be an important assessment in the decision-making process and can be assessed by maximum inspiratory (PImax) and expiratory pressures (PEmax), sniff nasal inspiratory (SNIP) and expiratory (SNEP) pressures. Body position appears to have a significant effect on respiratory muscle strength. The aim of this study was to observe the difference in peak values of SNIP and SNEP of the respiratory muscles measured in 2 different positions (seated and supine with 45° elevation) in subjects with ALS and a group of matched healthy subjects. Methods: This is a case–control study of subjects with ALS and healthy subjects. Spirometry and surface electromyography (EMG) of the sternocleidomastoid, scalene, rectus abdominis, and external oblique muscles were assessed during PImax and PEmax maneuvers in the seated position, and SNIP and SNEP in the seated and supine positions at 45° elevation (randomized). Results: SNEP values in the 45° elevation were lower than in the sitting position in ALS (70.3 ± 26.7 vs 57.3 ± 22.8 cm H2O, P =.041). SNIP and SNEP were lower in ALS in the 45° elevation compared with healthy subjects (69.1 ± 27.2 vs 95.5 ± 23.5 cm H2O; 57.3 ± 22.5 vs 92.7 ± 26.4 cm H2O, P =.041). In subjects with ALS, baseline electromyographic activity of the sternocleidomastoid muscle at rest was higher than in healthy subjects in both positions (P =.041). No significant differences in electrical activity were found for other variables and measurements. Conclusions: In ALS, nasal pressure may be affected by reduced diaphragm and abdominal muscle effectiveness in the supine position. The sternocleidomastoid muscle showed increased electrical activity in the supine position with 45° elevation compared with controls, which may indicate muscle weakness. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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