Normative Database and Determinants of Retinal and Choroidal Vessel Density in Tibetan Children.
Highlights: What are the main findings? Foveal retinal vessel density in Tibetan children is positively correlated with systemic oxygen saturation. The retinal microcirculation reflects adaptation to chronic hypoxia. What are the implications of the main findings? This study provides normative OCTA...
| Publicado en: | Children Vol. 13; no. 2; pp. 284 - 294 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
MDPI
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192108652&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192108652 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22279067 LW6K jtl: Children issn: 22279067 maglogo: N pubinfo: dt: Feb2026 vid: 13 iid: 2 pid: 97109 pub: MDPI artinfo: ui: 192108652 192108652 192108652 10.3390/children13020284 192108652 ppf: 284 ppct: 10 formats: tig: atl: Normative Database and Determinants of Retinal and Choroidal Vessel Density in Tibetan Children. aug: au: Meng, Zhaojun Yao, Yao Li, Lei Chen, Weiwei Fu, Jing affil: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China sug: subj: Databases, Health Evaluation Retina Blood Supply Uvea Blood Supply Retina Radiography Pediatric Care Tibet Reference Values Tomography, Optical Coherence Uvea Radiography Retina Anatomy and Histology Uvea Anatomy and Histology Human Male Female Child Tibet Students, Elementary Angiography Correlation Coefficient Age Factors Sex Factors Refraction, Ocular Oxygen Saturation Microcirculation Physiology Epidemiological Research Prospective Studies Biometrics Univariate Statistics Cross Sectional Studies Stratified Random Sample Slit Lamp Examination Microscopy Tonometry Blood Pressure Evaluation Heart Rate Evaluation Body Height Evaluation Body Weight Evaluation T-Tests Multiple Logistic Regression Multivariate Analysis Descriptive Statistics Data Analysis Software Funding Source Child: 6-12 years Male Female ab: Highlights: What are the main findings? Foveal retinal vessel density in Tibetan children is positively correlated with systemic oxygen saturation. The retinal microcirculation reflects adaptation to chronic hypoxia. What are the implications of the main findings? This study provides normative OCTA data for this unique pediatric population and identifies systemic oxygen saturation as a novel determinant of foveal vascular density. This study positions retinal vascular metrics as a potential non-invasive biomarker for systemic oxygen homeostasis and high-altitude adaptation. Background/Objectives: This study investigates the normative data and determinants of retinal and choroidal vessel density (VD) in Tibetan children using optical coherence tomography angiography (OCTA). Methods: This study recruited students from primary schools in Lhasa who underwent OCTA encompassing VD in the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) and choriocapillaris (CC) in the macular region, as well as refractive status, axial length, and systemic examinations. Results: This study included a total of 645 children who met the criteria. The results showed that VD in the fovea was significantly higher in the SCP than in the DCP, while CC had the highest VD in the fovea. Correlation analysis revealed strong correlations in VD among all quadrants of the SCP, DCP, and CC, as well as significant correlations between corresponding regions of the SCP and DCP. VD showed no significant association with age, sex, axial length, or spherical equivalent. Foveal VD in both the SCP and DCP was positively correlated with oxygen saturation. No consistent correlation was found between choroidal or retinal thickness and VD in any layer. Conclusions: The identified link between systemic oxygen saturation and foveal vascular density offers a novel perspective on human adaptation to chronic hypoxia, positioning the retinal microcirculation as a sensitive indicator of systemic oxygen homeostasis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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