A Systematic Review and Meta-Analysis of Executive Function Outcomes in Pediatric Central Nervous System Tumor Survivors.
Background: This review aimed to determine whether executive dysfunction is a characteristic of survivors of central nervous system tumors in children and adolescents, including Astrocytoma, Neurofibromatosis-1, Medulloblastoma, and Pilocytic Astrocytoma. Methods: A review and meta-analysis of execu...
| Publicado en: | Actas Espanolas de Psiquiatria Vol. 54; no. 1; pp. 237 - 263 |
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| Autor principal: | |
| Formato: | Artículo |
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Maria Lopez-Ibor
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=192138271&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 192138271 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11399287 IVZ jtl: Actas Espanolas de Psiquiatria issn: 11399287 maglogo: N pubinfo: dt: 2026 vid: 54 iid: 1 pid: 80014 pub: Maria Lopez-Ibor artinfo: ui: 192138271 10.62641/aep.v54i1.2053 ppf: 237 ppct: 26 formats: fmt: @attributes: type: P size: 3.7MB tig: atl: A Systematic Review and Meta-Analysis of Executive Function Outcomes in Pediatric Central Nervous System Tumor Survivors. aug: au: Herreras, Esperanza Bausela affil: Department of Health Sciences, Public University of Navarra, Campus de Arrosadia s/n, 31006 Pamplona, Comunidad Foral de Navarra, Spain su: Central nervous system tumors Executive function Neurofibromatosis 1 Cognition disorders Medulloblastoma Astrocytomas Research methodology Neuropsychological tests sug: subj: Central nervous system tumors Executive function Neurofibromatosis 1 Cognition disorders Medulloblastoma Astrocytomas Research methodology Neuropsychological tests keyword: astrocytoma BRIEF executive function medulloblastoma neurofibromatosis-1 pilocytic astrocytoma ab: Background: This review aimed to determine whether executive dysfunction is a characteristic of survivors of central nervous system tumors in children and adolescents, including Astrocytoma, Neurofibromatosis-1, Medulloblastoma, and Pilocytic Astrocytoma. Methods: A review and meta-analysis of executive function assessed with Behavior Rating Inventory of Executive Function (BRIEF) in individuals with these tumor types. Results: The main findings of the meta-analyses can be summarized as follows: (i) Neurofibromatosis type 1 (NF1) - BRIEF (parents): Children with NF1 show significant deficits in executive functions according to the parentrated BRIEF, with an overall model effect size of d = 0.81 (p < 0.001). The most affected areas are working memory, monitoring, and metacognition, indicating that these deficits are consistent and clinically relevant. (ii) NF1 - BRIEF-P (parents and teachers): In this meta-analysis, the overall model effect size was d = 0.37 (p < 0.001), showing moderate but significant difficulties in executive functions. Both parents and teachers report problems in working memory and emerging metacognition, reflecting a consistent pattern across different observational contexts. (iii) Medulloblastoma vs. other tumors: Patients with medulloblastoma exhibit marked deficits in executive functions compared to other brain tumors, with an overall model effect size of d = -0.74 (p < 0.001). The most affected areas include inhibition, initiation, regulation, and metacognition, with consistent findings across the included studies. Conclusions: Executive deficits are observed in individuals with brain tumors or survivors, significantly affecting their academic, social, and emotional lives. Early identification, along with educational and neuropsychological support, is essential to preventing these deficits from interfering with academic, personal, and professional functioning. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Actas Espanolas de Psiquiatria holder: Maria Lopez-Ibor dt: @attributes: year: 2026 holdings: @attributes: islocal: N |
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