Assessment of N/L ratio and subclinical atherosclerosis in FH subjects with or without LDLR mutation.
Background Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein-cholesterol (LDL-C) and increased cardiovascular risk. While the role of LDL-C in atherogenesis is well established, the contribution of inflammatory activation in FH, particularly i...
| Published in: | Journal of the Endocrine Society Vol. 10; no. 3; pp. 1 - 11 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
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Oxford University Press / USA
Mar2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192209579&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192209579 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 24721972 LBOG jtl: Journal of the Endocrine Society issn: 24721972 maglogo: N pubinfo: dt: Mar2026 vid: 10 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192209579 10.1210/jendso/bvag001 192209579 ppf: 1 ppct: 10 formats: tig: atl: Assessment of N/L ratio and subclinical atherosclerosis in FH subjects with or without LDLR mutation. aug: au: Barbagallo, Francesco Di Giacomo Bosco, Giosiana Marco, Maurizio Di Scilletta, Sabrina Miano, Nicoletta Martedì, Marina Privitera, Ivan Papa, Maria Chiara Piazza, Chiara Valenza, Francesca affil: Department of Clinical and Experimental Medicine, University of Catania, Catania 95123, ItalyDepartment of Medicine and Surgery, "Kore" University of Enna, Enna 94100, Italy sug: ab: Background Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein-cholesterol (LDL-C) and increased cardiovascular risk. While the role of LDL-C in atherogenesis is well established, the contribution of inflammatory activation in FH, particularly in relation to genotype, remains poorly defined. We aimed to evaluate the impact of genotype on neutrophil-to-lymphocyte ratio (NLR) and on subclinical atherosclerosis in a cohort of FH subjects. Methods We conducted a cross-sectional study on 423 FH subjects not on lipid-lowering therapy and free from atherosclerotic cardiovascular disease. Biochemical, genetic, and vascular assessments were performed in all participants. The population was divided into 2 groups based on genotype: low-density lipoprotein receptor (LDLR; n = 273) and non-LDLR (NLDLR, n = 150). Vascular profile was assessed by coronary artery calcium score and carotid/femoral plaque presence. NLR was calculated from peripheral blood counts. Results The LDLR group exhibited an higher NLR (2.27 ± 0.86 vs 2.05 ± 0.68, P <.05) than the NLDLR group. LDL-C levels and LDLR genotype were significantly associated with NLR (both P <.05). Multiterritorial plaque involvement was more frequent in the LDLR group than the NLDLR group (P for trend <.05). Age (P <.001), LDL-C (P <.001), smoking status (P <.05), and NLR (P <.05) were independently associated with subclinical atherosclerosis. Conclusion FH subjects with LDLR mutations had a higher NLR and a more severe atherosclerosis distribution. Our findings support the role of NLR as a noninvasive biomarker of early immune activation and highlights the importance of lipoinflammatory status evaluation in FH subjects. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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