Dysregulated Reward‐Inhibition Network Interactions During Food‐Cue Exposure in Disinhibited Restrained Eaters: Evidence From Task‐Based PPI and DCM.
Objective: Disinhibited restrained eaters are particularly susceptible to dietary lapses and are at increased risk for the onset of eating disorders. To elucidate the neural mechanisms underlying this vulnerability, the present study examined interactions between the reward and inhibition systems du...
| Publicado en: | International Journal of Eating Disorders Vol. 58; no. 12; pp. 2257 - 2271 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Dec2025
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192268589&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192268589 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 02763478 IJD jtl: International Journal of Eating Disorders issn: 02763478 maglogo: Y pubinfo: dt: Dec2025 vid: 58 iid: 12 pid: 480 pub: Wiley-Blackwell artinfo: ui: 192268589 10.1002/eat.24535 ppf: 2257 ppct: 14 formats: tig: atl: Dysregulated Reward‐Inhibition Network Interactions During Food‐Cue Exposure in Disinhibited Restrained Eaters: Evidence From Task‐Based PPI and DCM. aug: au: Wang, Shaorui Xiao, Mingyue Han, Jinfeng Cui, Yicen Chen, Hong affil: School of Psychology, Southwest University, Chongqing, China Key Laboratory of Cognition and Personality (Ministry of Education), Southwest University, Chongqing, China Research Center of Psychology and Social Development, Southwest University, Chongqing, China The Collaborative Innovation Team on Child and Adolescent Mental Health, Southwest University, Chongqing, China su: Task performance Satisfaction Food consumption Hunger Reward (Psychology) Eating disorders Food habits Brain physiology Prompts (Psychology) Functional connectivity Causal models Data analysis Research funding Visual analog scale Questionnaires Magnetic resonance imaging Descriptive statistics Statistics Neuroradiology Diet therapy Diet in disease sug: subj: Task performance Satisfaction Food consumption Hunger Reward (Psychology) Eating disorders Food habits Diagnostic Imaging Centers Brain physiology Prompts (Psychology) Functional connectivity Causal models Data analysis Research funding Visual analog scale Questionnaires Magnetic resonance imaging Descriptive statistics Statistics Neuroradiology Diet therapy Diet in disease keyword: disinhibition functional and effective connectivity inhibition system restrained eating reward system disinhibition functional and effective connectivity inhibition system restrained eating reward system ab: Objective: Disinhibited restrained eaters are particularly susceptible to dietary lapses and are at increased risk for the onset of eating disorders. To elucidate the neural mechanisms underlying this vulnerability, the present study examined interactions between the reward and inhibition systems during food cue exposure. Method: Sixty female restrained eaters (aged 17–26 years) completed a task‐based fMRI paradigm involving food and neutral cues under satiety. Participants were grouped by disinhibition level based on the Dutch Eating Behavior Questionnaire. Psychophysiological interaction (PPI) and dynamic causal modeling (DCM) were used to assess task‐modulated functional and effective connectivity. Disinhibited eating was behaviorally assessed via the eating in the absence of hunger (EAH) paradigm. Results: Disinhibited restrained eaters showed weaker functional connectivity between reward (e.g., putamen, globus pallidus [GP]) and inhibition (e.g., inferior frontal gyrus [IFG]) regions, as well as reduced excitatory modulation from reward to inhibition regions (GP → inferior parietal lobule [IPL]). This diminished effective connectivity significantly predicted greater caloric intake during the EAH task. Discussion: The study revealed a convergence of reduced functional and effective connectivity between the reward and inhibition systems in disinhibited restrained eaters. Both the synchrony and directional influence between these systems were weakened during food cue exposure. Notably, diminished excitatory modulation along the GP → IPL pathway significantly predicted greater caloric intake, suggesting this pathway may serve as a neural marker of vulnerability to disinhibited eating and dietary lapses. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|