Aldehyde Dehydrogenase 6 Family Member A1 Facilitates Ti Implant Osseointegration in Hyperlipidemia.
Objective: Hyperlipidemia seriously impairs titanium (Ti) implant osseointegration, and endogenous therapeutic targets remain elusive. Aldehyde dehydrogenase 6 family member A1 (ALDH6A1) plays an important role in redox regulation and lipid metabolism. However, its role in osseointegration under hyp...
| Publicado en: | Oral Diseases Vol. 31; no. 12; pp. 3437 - 3450 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192288889&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192288889 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1354523X DZP jtl: Oral Diseases issn: 1354523X maglogo: Y pubinfo: dt: Dec2025 vid: 31 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 192288889 186369929 192288889 192288889 10.1111/odi.15342 192288889 ppf: 3437 ppct: 13 formats: tig: atl: Aldehyde Dehydrogenase 6 Family Member A1 Facilitates Ti Implant Osseointegration in Hyperlipidemia. aug: au: Wang, Ya‐nan Yu, Lu Liu, Yingxue Xu, Xin Zhang, Dongjiao Liu, Shiyue Ge, Shaohua affil: Department of Implantology & Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan Shandong,, China sug: subj: Aldehyde Dehydrogenase Metabolism Hyperlipidemia Complications Osseointegration Drug Effects Genes Titanium Pharmacodynamics Dental Implants Hyperlipidemia Drug Therapy Osteoblasts Metabolism Animal Studies Mice Models, Biological In Vivo Studies In Vitro Studies Funding Source China Cell Culture Techniques Reverse Transcriptase Polymerase Chain Reaction Fluorescent Antibody Technique Staining and Labeling Blotting, Western T-Tests Comparative Studies One-Way Analysis of Variance Data Analysis Software Descriptive Statistics Oxidative Stress Lipid Peroxidation Reactive Oxygen Species Metabolism Gene Expression ab: Objective: Hyperlipidemia seriously impairs titanium (Ti) implant osseointegration, and endogenous therapeutic targets remain elusive. Aldehyde dehydrogenase 6 family member A1 (ALDH6A1) plays an important role in redox regulation and lipid metabolism. However, its role in osseointegration under hyperlipidemia conditions has not been thoroughly investigated. This study aimed to elucidate the potential role of ALDH6A1 in implant osseointegration in hyperlipidemia mice. Materials and Methods: ALDH6A1 expression levels were detected in peri‐implant tissue and in primary osteoblasts by qRT‐PCR and western blot. The role of ALDH6A1 in reducing oxidative damage and improving osseointegration on Ti implant surface was evaluated by locally overexpressing ALDH6A1 with a lentiviral vector in peri‐implant tissue in hyperlipidemia mice. Results: ALDH6A1 expression significantly decreased in hyperlipidemia mice, compared with normal mice (p < 0.05). ALDH6A1 was downregulated in a high‐fat environment, and silencing ALDH6A1 led to osteogenic dysfunction in osteoblasts. ALDH6A1 overexpression maintained redox homeostasis and osteogenic activity of primary osteoblasts and facilitated osseointegration in hyperlipidemia mice by reducing oxidative damage in peri‐implant tissue. Conclusion: ALDH6A1 is a key protein for facilitating osseointegration by alleviating reactive oxygen species levels in hyperlipidemia, and developing specific ALDH6A1 agonists would be a promising strategy for ameliorating osseointegration in hyperlipidemia patients. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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