Single-Agent Doxorubicin Adjuvant Chemotherapy for Resectable Grade 2/3 Soft Tissue Sarcomas: A Retrospective Study.
Background: Soft tissue sarcomas (STS) are rare but aggressive tumors. Although surgery and radiotherapy are standard treatments for localized STS, the role of adjuvant chemotherapy, particularly doxorubicin, in high-grade STS is debated. Methods: This retrospective study evaluated the effectiveness...
| Published in: | Oncology (08909091) Vol. 40; no. 2; pp. 106 - 115 |
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| Main Authors: | , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
MJH Life Sciences
Mar2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192305505&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192305505 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08909091 YYT jtl: Oncology (08909091) issn: 08909091 maglogo: N pubinfo: dt: Mar2026 vid: 40 iid: 2 pid: 54670 pub: MJH Life Sciences place: Cranbury, New Jersey artinfo: ui: 192305505 192305505 192305505 192305505 ppf: 106 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Single-Agent Doxorubicin Adjuvant Chemotherapy for Resectable Grade 2/3 Soft Tissue Sarcomas: A Retrospective Study. aug: au: Wu, Shiny Chih-Hsuan Wu, Yao-Yu Liau, Chi-Ting Chang, Chih-Hsiang Huang, Shih-Chiang Shih, Hsin-Nung Chen, Chun-Chieh affil: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing Street, Guishan District, Taoyuan City 333, Taiwan sug: subj: Sarcoma Surgery Neoplasm Grading Neoplasm Invasiveness Chemotherapy, Adjuvant Doxorubicin Therapeutic Use Sarcoma Drug Therapy Sarcoma Prognosis Human Retrospective Design Record Review Cancer Patients Male Female Adult Middle Age Taiwan T-Tests Wilcoxon Rank Sum Test Chi Square Test Fisher's Exact Test Kaplan-Meier Estimator Cox Proportional Hazards Model Confidence Intervals Descriptive Statistics Data Analysis Software Multiple Regression Univariate Statistics Surgical Patients Log-Rank Test Comparative Studies Overall Survival Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Soft tissue sarcomas (STS) are rare but aggressive tumors. Although surgery and radiotherapy are standard treatments for localized STS, the role of adjuvant chemotherapy, particularly doxorubicin, in high-grade STS is debated. Methods: This retrospective study evaluated the effectiveness of single-agent doxorubicin in resectable grade 2 and 3 STS, with a focus on oncologic outcomes. Adults with biopsy-confirmed STS of the extremities or trunk, treated at a tertiary center in Taiwan between January 2004 and March 2020, were included. Primary outcomes were distant metastasis-free survival (DMFS) and overall survival (OS). Results: The study enrolled 62 patients in either the single-agent doxorubicin adjuvant chemotherapy group (n = 8) or the observation-only group (n = 54). The mean age was 45.4 years in the adjuvant chemotherapy group and 58.2 years in the observation-only group. The 3-year OS was 100% in the chemotherapy group and 60% in the observation group (log-rank P = .064). The 3-year DMFS rate was 75% in the chemotherapy group and 45% in the observation group (log-rank P = .078). Conclusion: In resectable, high-grade STS of 8 cm or more, single-agent doxorubicin as adjuvant chemotherapy showed a trend toward improved OS and DMFS compared with observation alone; however, statistical significance was not reached. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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