Collaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma.
Background: There is a lack of prognosticators of overall survival (OS) for Oral Squamous Cell Carcinoma (OSCC). Objectives: We examined collaborative machine learning (cML) in estimating the OS of OSCC patients. The prognostic significance of the clinicopathological parameters was examined. Methodo...
| Publicado en: | Acta Oto-Laryngologica Vol. 146; no. 2; pp. 133 - 141 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192313090&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192313090 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: Feb2026 vid: 146 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 192313090 181966888 192313090 192313090 10.1080/00016489.2024.2437012 192313090 ppf: 133 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Collaborative machine learning-guided overall survival prediction of oral squamous cell carcinoma. aug: au: Alabi, Rasheed Omobolaji Elmusrati, Mohammed Leivo, Ilmo Almangush, Alhadi Mäkitie, Antti A. affil: Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland sug: subj: Machine Learning Mouth Neoplasms Prognosis Prediction Models Overall Survival Evaluation Carcinoma, Squamous Cell Prognosis Human Cancer Patients Disease Surveillance Logistic Regression Machine Learning Algorithms Cluster Sample Sensitivity and Specificity Neoplasm Staging Carcinoma, Squamous Cell Drug Therapy Chemotherapy, Cancer Funding Source Male Female Descriptive Statistics Male Female ab: Background: There is a lack of prognosticators of overall survival (OS) for Oral Squamous Cell Carcinoma (OSCC). Objectives: We examined collaborative machine learning (cML) in estimating the OS of OSCC patients. The prognostic significance of the clinicopathological parameters was examined. Methodology: Altogether, 9439 OSCC patients were extracted from the Surveillance, Epidemiology, and End Results database (US). Five ML models – voting ensemble, stacked ensemble, extreme gradient boosting, light boosting, and logistic regression were used to predict OS. Three of these ML algorithms were combined to form a cluster of cML models. The performance of the cML was compared with the best performing individual ML algorithm following model training. Results: The performance accuracy of the voting ensemble, stacked ensemble, extreme gradient boosting, light boosting, and logistic regression models was 70.2%, 69.9%, 69.1%, 69.4%, and 69.5% respectively, following model training. When the voting ensemble model was compared with cML using temporal validation, the cML showed a comparable performance accuracy. The most significant prognostic factors were age of the patient at diagnosis, T stage, tumor grade, marital status, gender, primary site, surgery, N stage, radiotherapy, ethnicity, chemotherapy, and M stage. Conclusions: cML appears to give reliability to the final prediction and thereby may mark a paradigm shift from model individualism to a more cooperative paradigm. This approach may aid in determining an enhanced individualized treatment for OSCC patients. 缺乏口腔鳞状细胞癌 (OSCC)总生存期 (OS) 的预测指标。 我们研究了协作机器学习 (cML) 在估计 OSCC 患者 OS 的作用。研究了临床病理参数的预后意义。 总共从监测、流行病学和最终结果数据库 (美国) 中提取了 9439 名 OSCC 患者。使用五种 ML 模型(投票集成、堆叠集成、极端梯度提升、轻度提升和逻辑回归)来预测 OS。将这些ML 算法中的三种组合在一起, 形成一个 cML 模型集群。将 cML 的性能与单个 ML 算法进行了比较。 投票集成、堆叠集成、极端梯度提升、轻度提升、逻辑回归和 cML 模型的性能准确度分别为 70.2%、69.2%、69.6%、69.7%、69.5% 和 72.8%。因此, cML 的性能准确度略有提高。预后因素按重要性降序排列为患者年龄、T 分期、肿瘤分级、婚姻状况、性别、原发部位、手术、N 分期、放疗、种族、化疗和 M 分期。 cML 为最终预测提供了可靠性, 从而标志着从模型个体性到更具综合性的范式转变。这种方法可能有助于确定针对 OSCC 患者的强化了的个体性治疗。 pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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