NaCl vs distilled water in wound healing – is traditional wound care still effective?
Aims To compare the effectiveness of distilled water (aquadest) and 0.9% sodium chloride (NaCl) in promoting wound healing, based on wound diameter, re-epithelialisation, granulation formation, neovascularisation and inflammatory response. Methods An in vivo experimental study was conducted using 27...
| Publicado en: | Wound Practice & Research Vol. 34; no. 1; pp. 1 - 10 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Cambridge Publishing
Mar2026
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192319605&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192319605 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18376304 639G jtl: Wound Practice & Research issn: 18376304 maglogo: N pubinfo: dt: Mar2026 vid: 34 iid: 1 pid: 66266 pub: Cambridge Publishing artinfo: ui: 192319605 192319605 192319605 10.33235/wpr.34.1.23-31 192319605 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: NaCl vs distilled water in wound healing – is traditional wound care still effective? aug: au: </strong>, <strong>Author(s) Wahab, Siswanto *, Khairuddin Djawad Miskad, Upik Cahyadi, Stefan Pelangi, Aurora affil: Department of Dermatology, Venereology andamp; Aesthetic, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia sug: subj: Normal Saline Therapeutic Use Water Therapeutic Use Wound Healing Wound Care Methods Therapeutic Irrigation Methods Rats Animal Studies Models, Biological Comparative Studies Indonesia In Vivo Studies Experimental Studies Wound Measurement Granulation Tissue Friedman Test Wilcoxon Rank Sum Test Confidence Intervals Inflammation Prevention and Control Descriptive Statistics Data Analysis Software Ketamine Administration and Dosage Sulfur Compounds Administration and Dosage Administration, Intraperitoneal ab: Aims To compare the effectiveness of distilled water (aquadest) and 0.9% sodium chloride (NaCl) in promoting wound healing, based on wound diameter, re-epithelialisation, granulation formation, neovascularisation and inflammatory response. Methods An in vivo experimental study was conducted using 27 male Wistar rats (Rattus norvegicus), randomly assigned into three groups (control, aquadest, and NaCl). Full-thickness wounds were created on the dorsum of each rat and treated daily for 14 days. On days 2, 7 and 14, the wounds were assessed macroscopically and histologically, quantitively and semi-qualitatively. Statistical analysis included Friedman and Wilcoxon tests, along with effect size calculations (Cohen's d and 95% confidence intervals). Results Aquadest significantly improved reepithelialisation (p=0.018), granulation tissue formation (p=0.022), and reduced inflammation (p= 0.039) compared to baseline. NaCl did not demonstrate statistically significant improvements across any parameter. Although wound diameter reduction in the aquadest group was not statistically significant (p=0.117), it showed a moderate-to-large effect size (d=0.78), with qualitative analysis showing the reduction of inflammatory cells and increase of neovascular count and epithelial thickness (p=0.040). Conclusions Distilled water showed superior performance to 0.9% NaCl in supporting multiple aspects of wound healing in a rat model. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|