Standardized Reporting of Core Needle Biopsy Tortuosity: BiopTort--A Computer-Aided Protocol for Categorizing Tortuosity.
Context.--Core needle biopsies (CNBs) are among the most common biopsy procedures, yielding long, thin deformation-prone cores. Core deformation results in both distorted histologic features and tortuosity (ie, deviation from the ideal straight path) along the length of the core. Tortuosity creates...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 150; no. 3; pp. 218 - 229 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192327256&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192327256 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Mar2026 vid: 150 iid: 3 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 192327256 192327256 192327256 10.5858/arpa.2025-0028-OA 192327256 ppf: 218 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Standardized Reporting of Core Needle Biopsy Tortuosity: BiopTort--A Computer-Aided Protocol for Categorizing Tortuosity. aug: au: Jacobs, Jackson Wiener, Dan Pathak, Tilak Farré, Xavier Mirtti, Tuomas Janowczyk, Andrew affil: Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, Georgia sug: subj: Pathology, Clinical Digital Imaging Biopsy, Needle Classification Reports Standards Computer-Aided Design Protocols Methods Pathologists Psychosocial Factors Human Descriptive Statistics Interrater Reliability Diagnostic Imaging Diagnosis, Computer Assisted Specimen Handling Histocytochemistry Productivity Comparative Studies Confidence Intervals ab: Context.--Core needle biopsies (CNBs) are among the most common biopsy procedures, yielding long, thin deformation-prone cores. Core deformation results in both distorted histologic features and tortuosity (ie, deviation from the ideal straight path) along the length of the core. Tortuosity creates challenges in slide preparation and downstream pathologist assessment (eg, absent diagnostically relevant tissue after sectioning), indicating a clinical need for its minimization. Despite this need, there is no standard protocol for reporting CNB tortuosity. Objectives.--To (1) establish an actionable protocol for scoring CNB tortuosity, (2) build BiopTort, a software tool assigning CNB images interpretable, tiered scores consistent with the protocol, and (3) investigate our protocol and BiopTort's impact on interpathologist concordance and scoring time. Design.--Using a held-out CNB data set (N = 167), 3 pathologists assessed tortuosity in 3 sequential stages: (1) Baseline: a 3-tier scale based on prior experience, (2) Protocol: rescored with our 4-tier Tortuosity Scoring Protocol, (3) BiopTort-Aided: rescored with the protocol alongside BiopTort. Interrater concordance for each stage, using the Fleiss j, was recorded. Results.--Fleiss j was 0.19, 0.40, and 0.63, and average time per slide was 8.0, 24.2, and 13.3 seconds for stages 1 to 3, respectively. BiopTort was statistically noninferior to human interrater pairwise concordance. Conclusions.--These results suggest our protocol lessens interpathologist variability, with BiopTort further reducing variability and scoring protocol employment time cost. When deployed in CNB quality control workflows, our computer-aided protocol appears well situated to facilitate standardized, efficient, and actionable reporting of CNB tortuosity. BiopTort is open-source (http://bioptort.com). pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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