Geographic disparities in accessibility to clinical studies for autoimmune skin disorders in the US: a retrospective review (2005–2024).
Equitable access to clinical studies is essential to ensuring that research findings are generalizable, inclusive, and reflective of all populations. When specific demographic or geographic groups are excluded from participation, the external validity of clinical research is undermined and inequitie...
| Publicado en: | Discover Public Health Vol. 23; no. 1; pp. 1 - 12 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
3/19/2026
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192415452&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192415452 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 30050774 NM7Z jtl: Discover Public Health issn: 30050774 maglogo: N pubinfo: dt: 3/19/2026 vid: 23 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 192415452 192415452 192415452 10.1186/s12982-026-01720-9 192415452 ppf: 1 ppct: 11 formats: tig: atl: Geographic disparities in accessibility to clinical studies for autoimmune skin disorders in the US: a retrospective review (2005–2024). aug: au: Alkurdi, Dany Shqair, Lara Tariq, Saniya Mehrzad, Sebastian Bear, Xavier Alani, Omar Patel, Dev Alkurdi, Ezdean Richmond, Jillian Schwager, Zachary affil: https://ror.org/04a9tmd77 Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA sug: subj: Race Factors Ethnic Groups Geographic Factors Autoimmune Diseases United States Skin Diseases United States Research Subject Recruitment Clinical Trials Human United States Medically Underserved Surveys Retrospective Design Record Review Software Linear Regression Descriptive Statistics T-Tests Asians Rural Population Native Americans Funding Source ab: Equitable access to clinical studies is essential to ensuring that research findings are generalizable, inclusive, and reflective of all populations. When specific demographic or geographic groups are excluded from participation, the external validity of clinical research is undermined and inequities in treatment access are perpetuated. Autoimmune skin disorders are uncommon and often affect patients living far from major research centers, yet no comprehensive analysis of national clinical study accessibility for these conditions has been conducted. We conducted a retrospective, population-level analysis of study accessibility for autoimmune skin disorders in the United States from 2005 to 2024 using ClinicalTrials.gov and U.S. Census data. Population centers were defined as geographic centroids of ZIP codes, and the distance from each population center to the nearest study site was calculated. Trend analyses assessed changes in accessibility over time and differences across racial and urban–rural categories. Although the number of studies has increased over time (approximately six additional studies annually), travel distances to the nearest study site remain substantial. The average distance has decreased modestly by about 3.4 km per year, but 40% of Americans still live more than 200 km from the closest study site, with the greatest distances observed among rural and American Indian populations. Expanding population coverage requires rapidly increasing travel distances. These findings highlight persistent disparities in access to clinical studies. While decentralization and virtual study models may help reduce these gaps, further research is needed to determine whether such strategies effectively improve participation and representation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|