Effect of Brain-Computer Interface-Controlled Ankle Robot Training on Post-Stroke Motor Rehabilitation and Resting QEEG Neuroplasticity: A Randomized Controlled Trial.
Background.: Persistent post-stroke ankle impairment hinders functional recovery. Brain-computer interface (BCI)-controlled ankle robot show rehabilitation potential, but their efficacy and underlying neuroplasticity remain unclear. Objective.: To assess BCI-controlled ankle robot training on post-s...
| Publicado en: | Neurorehabilitation & Neural Repair Vol. 40; no. 4; pp. 278 - 291 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Sage Publications Inc.
Apr2026
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192433707&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192433707 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459683 IRK jtl: Neurorehabilitation & Neural Repair issn: 15459683 maglogo: Y pubinfo: dt: Apr2026 vid: 40 iid: 4 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 192433707 191557757 192433707 192433707 10.1177/15459683251412286 192433707 ppf: 278 ppct: 13 formats: tig: atl: Effect of Brain-Computer Interface-Controlled Ankle Robot Training on Post-Stroke Motor Rehabilitation and Resting QEEG Neuroplasticity: A Randomized Controlled Trial. aug: au: Zhai, Xiaoxue Hao, Zexuan Wang, Xingui Li, Chong Cao, Yingyu Peng, Bo Qi, Xuewei Ni, Xueyi Xie, Ruimou Dou, Weibei Pan, Yu affil: Department of Rehabilitation Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China sug: subj: Stroke Rehabilitation Gait Disorders, Neurologic Rehabilitation Functional Training Methods Robotics Methods Brain-Computer Interfaces Ankle Joint Physiology Lower Extremity Physiology Neuronal Plasticity Evaluation Recovery Evaluation Motor Activity Evaluation Motor Skills Evaluation Electroencephalography Treatment Outcomes Human Male Female Adult Middle Age Aged Rehabilitation Patients Stroke Patients Inpatients China Rehabilitation Centers Randomized Controlled Trials Random Assignment Single-Blind Studies Comparative Studies Descriptive Statistics Data Analysis Software Unpaired T-Tests Fisher's Exact Test Wilcoxon Signed Rank Test Paired T-Tests Mann-Whitney U Test Post Hoc Analysis Analysis of Covariance Gait Training Biomechanics Questionnaires Range of Motion Activities of Daily Living Functional Assessment Muscle Strength Dorsiflexion Plantarflexion Muscle Spasticity Prevention and Control Functional Connectivity Balance, Postural Gait Analysis Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background.: Persistent post-stroke ankle impairment hinders functional recovery. Brain-computer interface (BCI)-controlled ankle robot show rehabilitation potential, but their efficacy and underlying neuroplasticity remain unclear. Objective.: To assess BCI-controlled ankle robot training on post-stroke lower-limb motor recovery and neuroplasticity using quantitative EEG (qEEG). Methods.: Thirty-two stroke patients were randomized to BCI (n = 16, 40-minute BCI-robot training) or control (n = 16, 40-minute ankle-robot training) groups, receiving 5 sessions/week for 2 weeks. Outcomes included Fugl-Meyer Assessment-Lower Extremity (FMA-LE), Berg Balance Scale (BBS), Functional Ambulatory Category (FAC), Modified Ashworth Scale (MAS), active range of motion (AROM), and muscle strength. QEEG assessed the relative power of the delta (rδ), theta (rθ), alpha (rα), beta (rβ) bands, spectral power ratios, pairwise-derived Brain Symmetry Index (pdBSI), and functional connectivity. Results.: Both groups showed significant within-group improvements in dorsiflexion AROM, dorsiflexor strength, FMA-LE, BBS, and FAC (P <.05). The BCI group demonstrated significantly greater FMA-LE improvement than controls (∆FMA-LE, P =.007) and reduced calf spasticity (MAS; P =.038). QEEG analysis in the BCI group revealed decreased rδ (P =.005), increased rα (P =.017), reduced DAR and DTABR (P <.05), reduced interhemispheric asymmetry (pdBSI-δ; P =.018), and enhanced Cz-parietal connectivity in α and β bands (P <.05). Conclusion.: BCI-controlled ankle robot training significantly improved lower-limb motor function and reduced spasticity post-stroke. Associated neurophysiological changes, characterized by reduced slow-wave power and asymmetry, increased alpha power, and functional connectivity, indicated beneficial neuroplastic reorganization. Clinical trial registration number: China Clinical Trail Registry (ChiCTR2300074381; URL: http://www.chictr.org.cn). pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|