CT-Based radiomics and deep learning for the preoperative prediction of peritoneal metastasis in ovarian cancers.
Objectives: To develop a CT-based deep learning radiomics nomogram (DLRN) for the preoperative prediction of peritoneal metastasis (PM) in patients with ovarian cancer (OC). Methods: A total of 296 patients with OCs were randomly divided into training dataset (N = 207) and test dataset (N = 89). The...
| Publicado en: | Abdominal Radiology Vol. 51; no. 4; pp. 2044 - 2058 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192481147&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192481147 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Apr2026 vid: 51 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 192481147 187294558 10.1007/s00261-025-05162-w 192481147 ppf: 2044 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: CT-Based radiomics and deep learning for the preoperative prediction of peritoneal metastasis in ovarian cancers. aug: au: Liu, Yanjun Yin, Huanying Li, Jiaojiao Wang, Zimeng Wang, Wenjiang Cui, Shujun affil: https://ror.org/03hqwnx39 Hebei North University, Zhangjiakou, China sug: ab: Objectives: To develop a CT-based deep learning radiomics nomogram (DLRN) for the preoperative prediction of peritoneal metastasis (PM) in patients with ovarian cancer (OC). Methods: A total of 296 patients with OCs were randomly divided into training dataset (N = 207) and test dataset (N = 89). The radiomics features and DL features were extracted from CT images of each patient. Specifically, radiomics features were extracted from the 3D tumor regions, while DL features were extracted from the 2D slice with the largest tumor region of interest (ROI). The least absolute shrinkage and selection operator (LASSO) algorithm was used to select radiomics and DL features, and the radiomics score (Radscore) and DL score (Deepscore) were calculated. Multivariate logistic regression was employed to construct clinical model. The important clinical factors, radiomics and DL features were integrated to build the DLRN. The predictive performance of the models was evaluated using the area under the receiver operating characteristic curve (AUC) and DeLong's test. Results: Nine radiomics features and 10 DL features were selected. Carbohydrate antigen 125 (CA-125) was the independent clinical predictor. In the training dataset, the AUC values of the clinical, radiomics and DL models were 0.618, 0.842, and 0.860, respectively. In the test dataset, the AUC values of these models were 0.591, 0.819 and 0.917, respectively. The DLRN showed better performance than other models in both training and test datasets with AUCs of 0.943 and 0.951, respectively. Decision curve analysis and calibration curve showed that the DLRN provided relatively high clinical benefit in both the training and test datasets. Conclusion: The DLRN demonstrated superior performance in predicting preoperative PM in patients with OC. This model offers a highly accurate and noninvasive tool for preoperative prediction, with substantial clinical potential to provide critical information for individualized treatment planning, thereby enabling more precise and effective management of OC patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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