Changing the Multiple Sclerosis Diagnostic Pathway: Insights From Stakeholders on Implementing Novel Radiological Biomarkers.
BACKGROUND: The multiple sclerosis (MS) diagnostic process can be lengthy and result in psychological distress and treatment delays. The 2024 revised McDonald diagnostic criteria incorporate the central vein sign (CVS) and paramagnetic rim lesions (PRL), radiological biomarkers that offer the potent...
| Publicado en: | International Journal of MS Care Vol. 28; no. 1; pp. 32 - 40 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Consortium of Multiple Sclerosis Centers
Jan/Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=192492769&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 192492769 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15372073 1FUA jtl: International Journal of MS Care issn: 15372073 maglogo: N pubinfo: dt: Jan/Feb2026 vid: 28 iid: 1 pid: 66082 pub: Consortium of Multiple Sclerosis Centers place: Hackensack, New Jersey artinfo: ui: 192492769 192492769 192492769 10.7224/1537-2073.2025-022 192492769 ppf: 32 ppct: 8 formats: tig: atl: Changing the Multiple Sclerosis Diagnostic Pathway: Insights From Stakeholders on Implementing Novel Radiological Biomarkers. aug: au: Gilmartin, Christopher Paskin, Thomas Shuen, Chloe Chieng Shiao de Dios Pérez, Blanca Clarke, Margareta Taylor, Lauren Evangelou, Nikos affil: School of Medicine, University of Nottingham, Nottingham, United Kingdom sug: subj: Multiple Sclerosis Diagnosis Diagnostic Imaging Biological Markers Diagnostic Use Attitude of Health Personnel Evaluation Patient Attitudes Evaluation Implementation Science Evaluation Uncertainty Demyelinating Diseases Diagnosis Magnetic Resonance Imaging Human Male Female Semi-Structured Interview Descriptive Statistics Focus Groups Health Care Delivery Healthcare Disparities Communication Multidisciplinary Care Team Support, Psychosocial Patient Satisfaction Cost Effectiveness Analysis Sensitivity and Specificity Data Analysis Software Pilot Studies Qualitative Studies Spinal Puncture Utilization Decision Making, Clinical United Kingdom Funding Source Male Female ab: BACKGROUND: The multiple sclerosis (MS) diagnostic process can be lengthy and result in psychological distress and treatment delays. The 2024 revised McDonald diagnostic criteria incorporate the central vein sign (CVS) and paramagnetic rim lesions (PRL), radiological biomarkers that offer the potential to improve the diagnostic pathway. METHODS: The study aims were to: (1) investigate the experiences of people with MS and health care professionals (HCPs) regarding the current diagnostic process, and (2) identify the barriers and facilitators to implementing the revised diagnostic criteria. Semistructured individual interviews and focus groups were conducted with 10 HCPs and 9 people with MS. Framework analysis, applying normalization process theory, was employed. RESULTS: Interviews revealed 4 themes: current challenges for the diagnostic pathway, CVS/PRL implementation barriers, the benefits of CVS/PRL implementation, and suggestions for overcoming implementation barriers and improving the diagnostic pathway . Challenges to implementation include pathway inefficiencies, care delivery inequality, insufficient communication, financial constraints, capacity limitations, and clinician hesitancy with the revised criteria. Suggested strategies for implementation and improvement included HCP training, enhancing interdisciplinary collaboration, evaluating implemented changes, and delivering emotional and practical support during diagnosis. Benefits for CVS/PRL implementation included reduced reliance on lumbar punctures, improved patient experience, cost-effectiveness, and enhanced diagnostic accuracy. CONCLUSIONS: Despite patient enthusiasm, implementing the revised diagnostic criteria will be challenging and possibly delayed unless HCP concerns are appropriately addressed. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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