Prevalence of frailty and its association with cognition in preclinical Alzheimer's disease: a cross-sectional analysis of baseline data from the A4 study.

Background The prevalence and role of frailty in preclinical Alzheimer's disease (AD) is unclear. Methods Cross-sectional analyses of pre-randomization data from the Anti-Amyloid Treatment in Asymptomatic AD (A4) study were analysed to derive two models of a frailty index (FI)—full [FI-Full] and cog...

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Bibliographic Details
Published in:	Age & Ageing Vol. 55; no. 1; pp. 1 - 11
Main Authors:	Huynh, Andrew L H, Wang, Shunran, Lee, Kathryn, Amadoru, Sanka, Wrigley, Scott, Zisis, Georgios, Ernstrom, Karin, Raman, Rema, Aisen, Paul, Sperling, Reisa A
Format:	Article
Published:	Oxford University Press / USA Jan2026
Subjects:	Australia Cross-sectional method Old age Alzheimer's disease diagnosis Pearson correlation (Statistics) Cognitive testing Research funding T-test (Statistics) Frail elderly Brain Logistic regression analysis Positron emission tomography Chi-squared test Multivariate analysis Descriptive statistics Odds ratio Amyloid Neuropsychological tests Cognition disorders Early diagnosis Data analysis software Confidence intervals Biomarkers Amyloid beta-protein precursor
Online Access:	View this record in EBSCOhost