Can dual-task high-velocity exercise training improve cognitive function in older adults? Secondary analysis of an 18-month cluster randomized controlled trial.
Background Identifying strategies to mitigate age-associated cognitive decline is crucial. High-velocity power training enhances physical function in older adults and cognitive training has mixed cognitive benefits, however the combined effects of these interventions remain uncertain. Objective This...
| Publicado en: | Age & Ageing Vol. 55; no. 1; pp. 1 - 16 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513126&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513126 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jan2026 vid: 55 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513126 10.1093/ageing/afaf385 ppf: 1 ppct: 15 formats: tig: atl: Can dual-task high-velocity exercise training improve cognitive function in older adults? Secondary analysis of an 18-month cluster randomized controlled trial. aug: au: Tait, Jamie L Duckham, Rachel L Rantalainen, Timo Milte, Catherine M Main, Luana C Nowson, Caryl A Sanders, Kerrie M Taaffe, Dennis R Hill, Keith D Abbott, Gavin affil: Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, 1 Gheringhap St, Geelong, Victoria, 3220, Australia Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, 1 Gheringhap St, Geelong, Victoria, 3220, AustraliaAustralian Institute for Musculoskeletal Science (AIMSS), Department of Medicine-Western Health, The University of Melbourne, Level 3 & 4, 176 Furlong Road, St Albans, Victoria, 3021, AustraliaDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Royal Parade, Parkville, Victoria, 3050, Australia Finnish Institute of High Performance Sport KIHU, Rautpohjankatu 6, FI-40700, Jyväskylä, Finland Department of Medicine, Western Health, The University of Melbourne, Level 3, 176 Furlong Road, St Albans, Victoria, 3021, Australia Exercise Medicine Research Institute and School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, 6027, Australia Rehabilitation Ageing and Independent Living (RAIL) Research Centre, Monash University, 47–49 Moorooduc Highway, Frankston, Victoria, 3199, Australia su: Attention Old age Dual-task paradigm Mental health surveys Cognitive testing Research funding Probability theory Questionnaires Treatment effectiveness Descriptive statistics Resistance training Genetic polymorphisms Psychology of movement Apolipoproteins Brain-derived neurotrophic factor Intraclass correlation Data analysis software Reaction time Short-term memory Cognitive aging Genotypes Physical activity sug: subj: Attention Old age Dual-task paradigm Mental health surveys Cognitive testing Research funding Probability theory Questionnaires Treatment effectiveness Descriptive statistics Resistance training Genetic polymorphisms Psychology of movement Apolipoproteins Brain-derived neurotrophic factor Intraclass correlation Data analysis software Reaction time Short-term memory Cognitive aging Genotypes Physical activity keyword: ageing apolipoprotein e brain-derived neurotrophic factor cognition cognitive ability copyrightHolder:British Geriatrics Society copyrightYear:2026 dual-task training executive functioning exercise follow-up genotype https://dx.doi.org/10.1093/ageing/afaf385 independent living inLanguage:en internship and residency isometric medical residencies memory mental processes older adult physical activity polymorphism power training publisher:Oxford University Press reaction time retirement community sameAs:https://pubmed.ncbi.nlm.nih.gov/41575070/ secondary data analysis short-term memory visual learning ageing apolipoprotein e brain-derived neurotrophic factor cognition cognitive ability copyrightHolder:British Geriatrics Society copyrightYear:2026 dual-task training executive functioning exercise follow-up genotype https://dx.doi.org/10.1093/ageing/afaf385 independent living inLanguage:en internship and residency isometric medical residencies memory mental processes older adult physical activity polymorphism power training publisher:Oxford University Press reaction time retirement community sameAs:https://pubmed.ncbi.nlm.nih.gov/41575070/ secondary data analysis short-term memory visual learning ab: Background Identifying strategies to mitigate age-associated cognitive decline is crucial. High-velocity power training enhances physical function in older adults and cognitive training has mixed cognitive benefits, however the combined effects of these interventions remain uncertain. Objective This 18-month cluster randomized controlled trial investigated whether dual-task functional power training (DT-FPT) enhances cognition in older adults and assessed if responses differ by apolipoprotein-E and brain-derived neurotrophic factor (BDNF) polymorphisms. Subjects and Methods Twenty-two independent-living retirement communities (300 residents, ≥65y at increased falls risk) were randomized to 12-months of group-based DT-FPT (6-months supervised +6-months maintenance, 45–60 minutes, 2/week) performed simultaneously with cognitive and/or motor tasks, followed by 6-months follow-up, or usual care control (CON). Cognitive domains were assessed using CogState at baseline, 6, 12 and 18-months. Z-scores were created to form composites for psychomotor-attention, learning-working memory and global cognition. BDNF and APOE polymorphism data were obtained from blood samples. Results Overall, 223 (74%) participants completed the 18-month intervention; mean exercise adherence was 50% at 6-months and 40% at 12-months. Net benefits in choice reaction time and attention (0.17 SD, P = 0.016), psychomotor-attention (0.19 SD, P = 0.029), and a composite of psychomotor-attention, learning-working memory (0.11 SD, P = 0.046) were detected in DT-FPT vs CON after the 6-month supervised phase. At 12 and 18 months, benefits from DT-FPT relative to CON were extended to visual learning (0.29 SD, P = 0.013; 0.27 SD, P = 0.008) and learning-working memory (0.13 SD, P = 0.047; 0.18 SD, P = 0.013). CON exhibited a 0.19 SD net benefit for executive function (P = 0.003) after 18 months. BDNF Met carriers at 18 months showed improved working memory (0.35 SD, P = 0.042) and learning-working memory (0.37 SD, P = 0.011) in DT-FPT versus CON. Conclusions In older retirement living residents, DT-FPT may improve cognitive domains critical for functional independence, with genotype potentially influencing these outcomes. Australian New Zealand Clinical Trials Registry (ACTRN12613001161718). This project was funded by the National Health and Medical Research Council (NHMRC) (APP1046267). pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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