Temporal dynamics of blood pressure, functional status and cognitive function in adults aged 85 years and older: a dynamic time warping approach in the Leiden 85-plus study.
Introduction High blood pressure (BP), functional decline, and cognitive decline commonly co-occur in late life. The temporal dynamics between changes in BP and changes in functional or cognitive status remain unclear. The aim of this study is to explore these temporal dynamics in adults aged 85 yea...
| Publicado en: | Age & Ageing Vol. 55; no. 1; pp. 1 - 10 |
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| Autores principales: | , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513132&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513132 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jan2026 vid: 55 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513132 10.1093/ageing/afag006 ppf: 1 ppct: 9 formats: tig: atl: Temporal dynamics of blood pressure, functional status and cognitive function in adults aged 85 years and older: a dynamic time warping approach in the Leiden 85-plus study. aug: au: Duin, Jan J Trompet, Stella Giltay, Erik Johnson, Jacob T Gussekloo, Jacobijn Poortvliet, Rosalinde R K E Mooijaart, Simon P van den Bos, Frederiek affil: Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsLUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands Department of Psychiatry, Leiden University Medical Center, Leiden, The NetherlandsHealth Campus The Hague, Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsLUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The NetherlandsDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands LUMC Center for Medicine for Older People, Leiden University Medical Center, Leiden, The NetherlandsDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands su: Netherlands Health status indicators Aging Activities of daily living Old age Statistical correlation Predictive tests Cognitive testing T-test (Statistics) Research funding Functional assessment Frail elderly Descriptive statistics Antihypertensive agents Longitudinal method Arterial pressure Neuropsychological tests Research Geriatric assessment Blood pressure Data analysis software Time Sensitivity & specificity (Statistics) Cognitive aging sug: subj: Health status indicators Aging Activities of daily living Old age Netherlands Pharmaceutical and medicine manufacturing Statistical correlation Predictive tests Cognitive testing T-test (Statistics) Research funding Functional assessment Frail elderly Descriptive statistics Antihypertensive agents Longitudinal method Arterial pressure Neuropsychological tests Research Geriatric assessment Blood pressure Data analysis software Time Sensitivity & specificity (Statistics) Cognitive aging keyword: activities of daily living adult antihypertensive agents blood pressure cognitive ability cognitive function cognitive impairment copyrightHolder:British Geriatrics Society copyrightYear:2026 diastolic blood pressure dynamic time warping factor v leiden functional status geriatrics https://dx.doi.org/10.1093/ageing/afag006 inLanguage:en instrumental activities of daily living mental processes mini-mental state examination octogenarians older adult publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41609320/ activities of daily living adult antihypertensive agents blood pressure cognitive ability cognitive function cognitive impairment copyrightHolder:British Geriatrics Society copyrightYear:2026 diastolic blood pressure dynamic time warping factor v leiden functional status geriatrics https://dx.doi.org/10.1093/ageing/afag006 inLanguage:en instrumental activities of daily living mental processes mini-mental state examination octogenarians older adult publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41609320/ ab: Introduction High blood pressure (BP), functional decline, and cognitive decline commonly co-occur in late life. The temporal dynamics between changes in BP and changes in functional or cognitive status remain unclear. The aim of this study is to explore these temporal dynamics in adults aged 85 years and older using dynamic time warping (DTW). Methods This study used data from the Leiden 85-plus Study. BP, functional status and cognitive function were measured at baseline (age 85) and annually over 5 years. Participants with at least three measurements were included (n = 429 of 599). Functional status was assessed using the Groningen Activity Restriction Scale for Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL). Cognitive function was measured with the Mini-Mental State Examination (MMSE). DTW was applied to assess temporal relationships. Results The 429 participants were all aged 85 years at baseline, 69% were female and 39% used antihypertensive medication. Increases in BP over time were associated with later IADL decline, while BP decreases were associated with later IADL improvement (P < .05). Similarly, decreases in diastolic BP over time were associated with later decreases in MMSE, while increases in diastolic BP were linked to later improvements in MMSE (P < .05). Conclusion BP changes were associated with subsequent inverse IADL changes over time, while changes in diastolic BP preceded concordant changes in cognitive function. These findings highlight the importance of BP changes in old age, as they might indicate later functional or cognitive decline. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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