Antibiotic use in older Australians with and without dementia in primary care.
Background Antibiotics are commonly prescribed in older community-dwelling adults, contributing to adverse effects, antimicrobial resistance and increased healthcare costs. Prescribing patterns in dementia are unclear, although healthcare use and goals of care change around diagnosis. Objective To d...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513143&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513143 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513143 10.1093/ageing/afag014 ppf: 1 ppct: 11 formats: tig: atl: Antibiotic use in older Australians with and without dementia in primary care. aug: au: Burvenich, Ruben Broder, Jonathan C Wang, Yiqing Verbakel, Jan Y Ryan, Joanne Orchard, Suzanne G Wolfe, Rory Ernst, Erika J Ernst, Michael E Nelson, Mark R affil: Department of Public Health and Primary Care, KU Leuven, Leuven, Flemish Brabant, BelgiumMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia Clinical and Translational Epidemiology Unit, Harvard Medical School, Boston, MA, USA Department of Public Health and Primary Care, KU Leuven, Leuven, Flemish Brabant, Belgium Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa Health Care, Iowa City, IA, USA Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa Health Care, Iowa City, IA, USADepartment of Family Medicine, Carver College of Medicine, University of Iowa Health Care, Iowa City, IA, USA Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia su: Australia Primary health care Sex distribution Hypertension Case-control method Psychological tests Alcohol drinking Mental depression Old age Diagnosis of dementia Antibiotics Risk assessment Mathematical variables Tetracyclines Hyperlipidemia Family medicine Medical prescriptions Research funding Statistical sampling Multiple regression analysis Antimicrobial stewardship Beta lactam antibiotics Frail elderly Disease prevalence Trend analysis Polypharmacy Time series analysis Descriptive statistics Intravenous therapy Longitudinal method Quinolone antibacterial agents Neuropsychological tests Medical records Acquisition of data Research Physician practice patterns Comparative studies Data analysis software Confidence intervals Drug prescribing Aminoglycosides Dementia patients Drug utilization Penicillin sug: subj: Primary health care Sex distribution Hypertension Case-control method Psychological tests Alcohol drinking Mental depression Old age Australia Pharmaceuticals and pharmacy supplies merchant wholesalers Drugs and Druggists' Sundries Merchant Wholesalers Pharmaceutical and medicine manufacturing Medicinal and Botanical Manufacturing Drinking Places (Alcoholic Beverages) Marketing Research and Public Opinion Polling Diagnosis of dementia Antibiotics Risk assessment Mathematical variables Tetracyclines Hyperlipidemia Family medicine Medical prescriptions Research funding Statistical sampling Multiple regression analysis Antimicrobial stewardship Beta lactam antibiotics Frail elderly Disease prevalence Trend analysis Polypharmacy Time series analysis Descriptive statistics Intravenous therapy Longitudinal method Quinolone antibacterial agents Neuropsychological tests Medical records Acquisition of data Research Physician practice patterns Comparative studies Data analysis software Confidence intervals Drug prescribing Aminoglycosides Dementia patients Drug utilization Penicillin keyword: antibiotic dispensing antibiotics antimicrobial stewardship australians copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia diagnosis general practice https://dx.doi.org/10.1093/ageing/afag014 inLanguage:en older adult older adults publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41627308/ antibiotic dispensing antibiotics antimicrobial stewardship australians copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia diagnosis general practice https://dx.doi.org/10.1093/ageing/afag014 inLanguage:en older adult older adults publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41627308/ ab: Background Antibiotics are commonly prescribed in older community-dwelling adults, contributing to adverse effects, antimicrobial resistance and increased healthcare costs. Prescribing patterns in dementia are unclear, although healthcare use and goals of care change around diagnosis. Objective To describe trends in antibiotic dispensing and prevalence amongst Australians aged ≥70 years, compare dispensing between those with and without dementia and identify factors associated with dispensing. Methods We analysed data from 13 659 ASPREE and ASPREE-XT participants (2010–20). Antibiotic dispensing was assessed using Pharmaceutical Benefits Scheme records, with rates stratified by age group. Interrupted time-series analysis compared dispensing rates and the proportion of broad- versus narrow-spectrum antibiotics dementia case and matched controls (matched on time since randomisation, age and sex). Negative binomial regression identified factors associated with dispensing. Results Dispensing rates increased to 1651 per 1000 person-years (95% CI: 1604–99) by year 9. Annual prevalence averaged 47%. Broad-spectrum antibiotics were dispensed twice as often as narrow-spectrum. Individuals with dementia had higher dispensing both before and after diagnosis, but dementia was not independently associated with dispensing (IRR 1.06, 95% CI: 0.95–1.18). Female sex, polypharmacy, pre-frailty and higher depressive symptom scores were linked to higher dispensing, whilst hypertension, dyslipidaemia and alcohol use were linked to lower dispensing. Conclusions Antibiotic dispensing in older adults remains high, dominated by broad-spectrum agents. Dementia was not independently associated with increased dispensing. Female sex, polypharmacy, pre-frailty and depressive symptoms identified groups who may benefit most from targeted antimicrobial stewardship interventions. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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