Risk of dementia and related neurocognitive disorders among autistic and non-autistic older adults: role of established risk factors.
Background Neurocognitive disorders (i.e. dementia) are a leading cause of cognitive decline and loss of independence among older adults. While reported rates are higher among autistic adults, it is unclear whether this disparity persists after accounting for known risk factors. Objective We compare...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 10 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Feb2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513144&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513144 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513144 10.1093/ageing/afag015 ppf: 1 ppct: 9 formats: tig: atl: Risk of dementia and related neurocognitive disorders among autistic and non-autistic older adults: role of established risk factors. aug: au: Nikahd, Melica Hyer, Madison Wolf, Beth Patterson, Brian Bishop, Lauren Hand, Brittany affil: Center for Biostatistics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA Division of Biostatistics, Medical University of South Carolina, Charleston, SC, USA Berbee Walsh Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, USA Waisman Center, University of Wisconsin-Madison, Madison, WI, USASandra Rosenbaum School of Social Work, University of Wisconsin-Madison, Madison, WI, USA Division of General Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA su: United States Autism Hypertension Smoking Medicare Retrospective studies Intellectual disabilities Alcoholism Mental depression Obesity Old age Dementia risk factors Cognition disorder risk factors Risk assessment Hypercholesteremia Statistical significance Research funding Questionnaires Descriptive statistics Longitudinal method Medical records Acquisition of data Type 2 diabetes Asperger's syndrome Hearing disorders Brain injuries Data analysis software Disease complications sug: subj: Autism Hypertension Smoking Medicare Retrospective studies Intellectual disabilities Alcoholism Mental depression Obesity Old age United States Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs) Dementia risk factors Cognition disorder risk factors Risk assessment Hypercholesteremia Statistical significance Research funding Questionnaires Descriptive statistics Longitudinal method Medical records Acquisition of data Type 2 diabetes Asperger's syndrome Hearing disorders Brain injuries Data analysis software Disease complications keyword: ageing autism autistic disorder copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia https://dx.doi.org/10.1093/ageing/afag015 inLanguage:en medicare neurocognitive disorders older adult older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41638232/ ageing autism autistic disorder copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia https://dx.doi.org/10.1093/ageing/afag015 inLanguage:en medicare neurocognitive disorders older adult older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41638232/ ab: Background Neurocognitive disorders (i.e. dementia) are a leading cause of cognitive decline and loss of independence among older adults. While reported rates are higher among autistic adults, it is unclear whether this disparity persists after accounting for known risk factors. Objective We compared neurocognitive disorder risk between autistic and non-autistic older adults after adjusting for known risk factors and evaluated whether risk factors moderated this disparity. We replicated our analyses among subsets of autistic older adults with and without co-occurring intellectual disability (ID). Design Retrospective longitudinal cohort study. Setting National Medicare Standard Analytical Files (2013–21). Participants The sample included 9201 autistic and 18 356 non-autistic older adults aged 65 or older, who were matched on demographic and clinical characteristics. Methods Our dependent variable was time to neurocognitive disorder, defined as years between age 65 or older and the date of first diagnosis. Results Autistic older adults had a 20% higher adjusted risk of neurocognitive disorders than non-autistic older adults (95% CI = 14%–25%; P < .001). Risk was highest among autistic adults with co-occurring ID [adjusted subhazard ratio (SHR) = 1.46; 95% CI = 1.36–1.57]. The disparity between cohorts was amplified in the presence of most known risk factors, notably hypertension (SHR = 2.04; 95% CI = 1.79–2.32), high cholesterol (SHR = 1.60; 95% CI = 1.46–1.75), depression (SHR = 1.52; 95% CI = 1.42–1.62), and type 2 diabetes (SHR = 1.45; 95% CI = 1.36–1.55). Conclusions Autistic older adults, particularly those with ID, face significantly higher risk of neurocognitive disorders even after adjusting for known risk factors. These findings emphasise that risk factors may impact the autistic population differently and highlight the need for early screening and tailored prevention strategies. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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