Adipose dysfunction, lipid dysregulation, and adipokines in sarcopenia: a systematic review and meta-analysis with sex-specific analyses.
Background Sarcopenia is increasingly recognised as a systemic metabolic disorder involving lipid dysregulation, adipose tissue dysfunction, and adipokine imbalance. However, there is a lack of quantitative synthesis with sex-specific analyses. Methods Following PRISMA 2020 guidelines, we searched P...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 20 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Feb2026
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513148&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513148 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513148 10.1093/ageing/afag020 ppf: 1 ppct: 19 formats: tig: atl: Adipose dysfunction, lipid dysregulation, and adipokines in sarcopenia: a systematic review and meta-analysis with sex-specific analyses. aug: au: Vithran, Djandan Tadum Arthur Hassan, Mahamat Hassan Yacoub Rahmati, Masoud Boyer, Laurent Wehliye, Awil Abdi Xiao, Wenfeng Li, Yusheng affil: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China CEReSS, Health Service Research and Quality of Life Center, AP-HM, Aix-Marseille University, Marseille, Provence-Alpes-Côte d'Azur, FranceCRSMP, Center for Mental Health and Psychiatry Research–Provence-Alpes-Côte d'Azur, Marseille, FranceDepartment of Physical Education and Sport Sciences, Lorestan University, Khorramabad, Lorestan, IranDepartment of Physical Education and Sport Sciences, Vali-e-Asr University of Rafsanjan, Rafsanjan, Kerman, Iran CEReSS, Health Service Research and Quality of Life Center, AP-HM, Aix-Marseille University, Marseille, Provence-Alpes-Côte d'Azur, FranceCRSMP, Center for Mental Health and Psychiatry Research–Provence-Alpes-Côte d'Azur, Marseille, France su: Sex distribution Aging Lipid metabolism Adipokines Adipose tissues Leptin Research funding Body composition Meta-analysis Descriptive statistics Systematic reviews MEDLINE Waist circumference Medical databases Lean body mass Online information services Data analysis software Sarcopenia Biomarkers Tumor necrosis factors Interleukins sug: subj: Sex distribution Aging Lipid metabolism Adipokines Adipose tissues Leptin Research funding Body composition Meta-analysis Descriptive statistics Systematic reviews MEDLINE Waist circumference Medical databases Lean body mass Online information services Data analysis software Sarcopenia Biomarkers Tumor necrosis factors Interleukins keyword: adipokines adipose dysfunction copyrightHolder:British Geriatrics Society copyrightYear:2026 heterogeneity high density lipoprotein cholesterol https://dx.doi.org/10.1093/ageing/afag020 inflammation inflammatory markers inLanguage:en interleukin-6 ldl cholesterol lipoproteins lipid metabolism lipids meta-analysis obesity older people publication bias publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41642178/ sarcopenia sex differences systematic review adipokines adipose dysfunction copyrightHolder:British Geriatrics Society copyrightYear:2026 heterogeneity high density lipoprotein cholesterol https://dx.doi.org/10.1093/ageing/afag020 inflammation inflammatory markers inLanguage:en interleukin-6 ldl cholesterol lipoproteins lipid metabolism lipids meta-analysis obesity older people publication bias publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41642178/ sarcopenia sex differences systematic review ab: Background Sarcopenia is increasingly recognised as a systemic metabolic disorder involving lipid dysregulation, adipose tissue dysfunction, and adipokine imbalance. However, there is a lack of quantitative synthesis with sex-specific analyses. Methods Following PRISMA 2020 guidelines, we searched PubMed, Scopus, Web of Science, Cochrane Library, CNKI, WanFang, and VIP for studies published from January 2015 to December 2024 that compared lipid panels, adipokines, adiposity, muscle indices, and inflammatory markers in sarcopenic and non-sarcopenic adults. Random-effects meta-analyses and meta-regression were performed. Heterogeneity was assessed using I statistics, and publication bias was evaluated with funnel plots and Trim-and-Fill procedures. Results Fifty-two studies (N > 30 000) met the inclusion criteria. Sarcopenia was associated with a modest increase in LDL-C (SMD = 0.13; P = .0022), particularly in females (SMD = 0.46). HDL-C levels significantly increased in females (SMD = 6.71; P = .03). No significant changes were observed for triglycerides, total cholesterol, adiponectin, or leptin. Waist circumference increased significantly (SMD = 5.82 cm; P = .25), and muscle indices (SMI, ASMI, SMM) were lower in sarcopenia. Inflammatory markers (TNF-α, IL-6, IL-8) showed no significant associations. Subgroup analyses revealed significant effects by sex, measurement methods, and sarcopenia definitions, with meta-regression indicating these factors influenced lipid marker changes. Conclusion This meta-analysis integrates lipid fractions, adipokines, adiposity markers, and sex-specific differences in sarcopenia. Our findings highlight the significant rise in HDL-C in females and suggest the need for sex-targeted interventions. Further longitudinal studies are needed to clarify causality and refine clinical practice in sarcopenia management. The protocol was registered on PROSPERO (CRD42024626636). pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|