Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.
Background In younger individuals, fitness is mostly influenced by muscle mitochondrial oxidative phosphorylation (OxPhos) and cardiac output. However, compared with younger individuals, various impairments may also negatively affect fitness in older adults. Objective To investigate the relationship...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 10 |
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| Autores principales: | , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Feb2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513150&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513150 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513150 10.1093/ageing/afag022 ppf: 1 ppct: 9 formats: tig: atl: Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing. aug: au: Trevisan, Caterina Tian, Qu Fishbein, Kenneth W Church, Sarah Simonsick, Eleanor M Egan, Josephine M Volpato, Stefano Ferrucci, Luigi affil: Department of Medical Sciences, University of Ferrara, Ferrara, Emilia-Romagna, ItalyAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden Longitudinal Studies Section (LSS), Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USAClinical Research Core (CRC), National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA Clinical Research Core (CRC), National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA Department of Medical Sciences, University of Ferrara, Ferrara, Emilia-Romagna, Italy su: Maryland Cross-sectional method Human beings Aging Physical fitness Analysis of variance Mitochondrial physiology Muscle physiology Psychological resilience Pearson correlation (Statistics) Research funding Oxidative stress Chi-squared test Descriptive statistics Walking Energy metabolism Aerobic exercises Phosphocreatine Data analysis software Confidence intervals Regression analysis sug: subj: Cross-sectional method Human beings Aging Physical fitness Analysis of variance Maryland Fitness and Recreational Sports Centers Mitochondrial physiology Muscle physiology Psychological resilience Pearson correlation (Statistics) Research funding Oxidative stress Chi-squared test Descriptive statistics Walking Energy metabolism Aerobic exercises Phosphocreatine Data analysis software Confidence intervals Regression analysis keyword: ageing aging cardiorespiratory fitness cohort study copyrightHolder:British Geriatrics Society copyrightYear:2026 energetic cost of walking https://dx.doi.org/10.1093/ageing/afag022 inLanguage:en mitochondria older adult older people oxidative phosphorylation physical fitness polymerase chain reaction psychological publisher:Oxford University Press resilience sameAs:https://pubmed.ncbi.nlm.nih.gov/41649296/ ageing aging cardiorespiratory fitness cohort study copyrightHolder:British Geriatrics Society copyrightYear:2026 energetic cost of walking https://dx.doi.org/10.1093/ageing/afag022 inLanguage:en mitochondria older adult older people oxidative phosphorylation physical fitness polymerase chain reaction psychological publisher:Oxford University Press resilience sameAs:https://pubmed.ncbi.nlm.nih.gov/41649296/ ab: Background In younger individuals, fitness is mostly influenced by muscle mitochondrial oxidative phosphorylation (OxPhos) and cardiac output. However, compared with younger individuals, various impairments may also negatively affect fitness in older adults. Objective To investigate the relationship of OxPhos with cardiorespiratory fitness, the energetic cost of walking and aerobic resilience with respect to age. Design Cross-sectional. Setting Population. Subjects Six hundred and forty-nine Baltimore longitudinal study of ageing participants (mean age 64.5 years, 56.9% females). Methods Muscle mitochondrial OxPhos was measured as phosphocreatine recovery rate (k) through P magnetic resonance spectroscopy. Based on age- and sex-specific k z-scores, we classified individuals with low (≤ −0.5 standard deviations [SD]), average (−0.5 to 0.5SD) and high (>0.5SD) OxPhos. Cardiorespiratory fitness was measured as peak oxygen consumption (MVO peak) during a treadmill testing. The energetic cost of usual pace walking was expressed as the average oxygen consumption per 100 metres. Aerobic resilience was the ratio between MVO peak and average VO during usual pace walking. Results Participants with higher k had 4.07 (95%CI: 2.88, 5.26) ml/kg/min higher MVO peak and 0.19 (95%CI: 0.06, 0.32) higher aerobic resilience than those with lower k. The energetic cost of walking was greater by 0.84 (95% CI: 0.21, 1.47) ml/kg/100 m in those with high than low k. A multiplicative interaction between age and k was identified in the regressions predicting MVO peak and aerobic resilience (p = 0.01), with differences between OxPhos groups attenuating after age 70. Conclusion Muscle mitochondrial OxPhos contributes to interindividual variability in cardiorespiratory fitness, especially in young and middle adulthood. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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