Comparative prognostic value of three frailty-assessment tools in older patients with heart failure: post hoc analysis of the FRAGILE-HF cohort.
Background In older patients with heart failure, frailty assessment tools potentially have different prognostic value for all-cause mortality. Objective To compare the Frailty Screening Index (FSI), FRAIL scale and Fried phenotype. Design Post hoc analysis of the FRAGILE-HF study. Subjects Hospitali...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513159&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513159 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513159 10.1093/ageing/afag031 ppf: 1 ppct: 11 formats: tig: atl: Comparative prognostic value of three frailty-assessment tools in older patients with heart failure: post hoc analysis of the FRAGILE-HF cohort. aug: au: Nakade, Taisuke Maeda, Daichi Matsue, Yuya Kagiyama, Nobuyuki Fujimoto, Yudai Ikeda, Yoshiaki Sunayama, Tsutomu Taishi, Dotare Jujo, Kentaro Saito, Kazuya affil: Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Graduate School of Medicine, Tokyo, Japan Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Graduate School of Medicine, Tokyo, JapanDepartment of Cardiology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine, Graduate School of Medicine, Tokyo, JapanDepartment of Cardiology, Sakakibara Heart Institute of Okayama, Okayama, Japan Department of Cardiology, Nishiarai Heart Centre Hospital, Tokyo, Japan Department of Rehabilitation, Sakakibara Heart Institute of Okayama, Okayama, Japan su: Japan Health status indicators Interviewing Age distribution Decision making Causes of death Hospital care of older people Psychosocial factors Old age Skeletal muscle physiology Predictive tests Risk assessment Receiver operating characteristic curves Data analysis Research funding Frail elderly Questionnaires Fisher exact test Kruskal-Wallis Test Hemoglobins Heart failure Peptide hormones Disease prevalence Functional status Chi-squared test Descriptive statistics Kaplan-Meier estimator Electrocardiography Log-rank test Geriatric assessment Statistics One-way analysis of variance Comparative studies Prognosis Exercise tests Confidence intervals Body movement Walking speed Data analysis software Phenotypes Proportional hazards models Time Sensitivity & specificity (Statistics) Grip strength Muscle contraction Nonparametric statistics sug: subj: Health status indicators Interviewing Age distribution Decision making Causes of death Hospital care of older people Psychosocial factors Old age Japan Skeletal muscle physiology Predictive tests Risk assessment Receiver operating characteristic curves Data analysis Research funding Frail elderly Questionnaires Fisher exact test Kruskal-Wallis Test Hemoglobins Heart failure Peptide hormones Disease prevalence Functional status Chi-squared test Descriptive statistics Kaplan-Meier estimator Electrocardiography Log-rank test Geriatric assessment Statistics One-way analysis of variance Comparative studies Prognosis Exercise tests Confidence intervals Body movement Walking speed Data analysis software Phenotypes Proportional hazards models Time Sensitivity & specificity (Statistics) Grip strength Muscle contraction Nonparametric statistics keyword: copyrightHolder:British Geriatrics Society copyrightYear:2026 foam stability index frail elderly frailty fried foods heart failure https://dx.doi.org/10.1093/ageing/afag031 inLanguage:en mortality older adult older people patient prognosis phenotype physical functional performance prognosis publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41734100/ copyrightHolder:British Geriatrics Society copyrightYear:2026 foam stability index frail elderly frailty fried foods heart failure https://dx.doi.org/10.1093/ageing/afag031 inLanguage:en mortality older adult older people patient prognosis phenotype physical functional performance prognosis publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41734100/ ab: Background In older patients with heart failure, frailty assessment tools potentially have different prognostic value for all-cause mortality. Objective To compare the Frailty Screening Index (FSI), FRAIL scale and Fried phenotype. Design Post hoc analysis of the FRAGILE-HF study. Subjects Hospitalised patients (age ≥ 65 years) with heart failure. Methods We assessed frailty status at discharge, considered preadmission conditions of patients, using the FSI, FRAIL scale and Fried phenotype models and evaluated the primary outcome (2-year all-cause mortality), prognostic performance using Cox regression analysis (adjusted for the Meta-analysis Global Group in Chronic Heart Failure risk score and log-transformed B-type natriuretic peptide) and discriminative and reclassification abilities (area under the receiver-operating characteristic curve and continuous net reclassification improvement, respectively). Results Among 961 patients [median age: 80 (IQR, 74–85) years; 41.5% women], frailty was identified in 48.5%, 44.5% and 55.8% by the FSI, FRAIL scale and Fried models, respectively. During the 2-year follow-up, 187 (19.5%) patients died. On Kaplan–Meier analysis, frailty defined by the FRAIL and Fried was associated with significantly lower survival; FSI showed no significant difference. Adjusted Cox models showed that frailty was independently associated [HR (95% CI)] with mortality in FRAIL [1.31 (1.01–1.71)] and Fried [1.35 (1.04–1.75)] but not FSI [1.11 (0.84–1.37)]. The Fried model, incorporated into the baseline model, yielded the highest incremental prognostic value for 2-year all-cause mortality. Conclusions Frailty assessment using different tools yields varying results, with notable differences in their prognostic value for 2-year all-cause mortality. The frailty assessment tool influences both frailty classification and risk stratification and warrants careful clinical selection. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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