Association of frailty with dementia and the impact of frailty on antihypertensive treatment protection against dementia in older hypertensive adults.
Background The relationship between frailty and dementia risk in hypertensive patients remains unclear, as does the impact of frailty on the effectiveness of antihypertensive treatment in preventing dementia. Methods Using data from the Systolic Hypertension in the Elderly Program trial, a baseline...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 10 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513165&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513165 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513165 10.1093/ageing/afag037 ppf: 1 ppct: 9 formats: tig: atl: Association of frailty with dementia and the impact of frailty on antihypertensive treatment protection against dementia in older hypertensive adults. aug: au: Chen, Linan You, Shoujiang Ee, Nicole Rockwood, Kenneth Ward, David D Hubbard, Ruth E Woodward, Mark Fitzgerald, Oisin Wang, Ruirui Gao, Yijie affil: The George Institute for Global Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia The George Institute for Global Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, AustraliaDepartment of Neurology and Clinical Research Center of Neurological Disease, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Division of Neurology, Dalhousie University Department of Medicine, Halifax, Nova Scotia, CanadaDivision of Geriatric Medicine, Dalhousie University Department of Medicine, Halifax, Nova Scotia, CanadaFrailty and Elder Care Network, Halifax, Nova Scotia, Canada Australian Frailty Network, Centre for Health Services Research, The University of Queensland Faculty of Health and Behavioural Sciences, Brisbane, Queensland, AustraliaPrincess Alexandra Hospital, Woolloongabba, Queensland, Australia The George Institute for Global Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, AustraliaThe George Institute for Global Health, Imperial College London School of Public Health, London, England, UK National Perinatal Epidemiology and Statistics Unit, University of New South Wales, Sydney, New South Wales, Australia The George Institute for Global Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, AustraliaDepartment of Epidemiology, Suzhou Medical College of Soochow University School of Public Health, Suzhou, Jiangsu, China su: United States Hypertension Blind experiment Randomized controlled trials Old age Dementia risk factors Dementia prevention Risk assessment Research funding Data analysis Statistical hypothesis testing Frail elderly Statistical sampling Antihypertensive agents Treatment effectiveness Mann Whitney U Test Descriptive statistics Odds ratio Statistics Dementia Confidence intervals Data analysis software Regression analysis Disease incidence Evaluation Disease complications sug: subj: Hypertension Blind experiment Randomized controlled trials Old age United States Pharmaceutical and medicine manufacturing Marketing Research and Public Opinion Polling Dementia risk factors Dementia prevention Risk assessment Research funding Data analysis Statistical hypothesis testing Frail elderly Statistical sampling Antihypertensive agents Treatment effectiveness Mann Whitney U Test Descriptive statistics Odds ratio Statistics Dementia Confidence intervals Data analysis software Regression analysis Disease incidence Evaluation Disease complications keyword: aged antihypertensive agents clinical trial copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia frailty https://dx.doi.org/10.1093/ageing/afag037 hypertension inLanguage:en older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41739751/ aged antihypertensive agents clinical trial copyrightHolder:British Geriatrics Society copyrightYear:2026 dementia frailty https://dx.doi.org/10.1093/ageing/afag037 hypertension inLanguage:en older people publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41739751/ ab: Background The relationship between frailty and dementia risk in hypertensive patients remains unclear, as does the impact of frailty on the effectiveness of antihypertensive treatment in preventing dementia. Methods Using data from the Systolic Hypertension in the Elderly Program trial, a baseline frailty index (FI) including 55 health deficits was constructed. Multinomial regression models were used to examine the association between frailty and dementia, as well as to examine whether the impact of antihypertensive treatment on the risk of dementia was modified by baseline FI. Results A total of 4692 participants (mean age: 72.1 years, 56.8% female) were included with a median (inter-quartile interval) FI of 0.127 (0.091–0.173). During a median follow-up of 4.4 years, 81 dementia cases occurred. Each SD (0.061) increase in FI was associated with a 33% higher risk of dementia [odds ratio (OR): 1.33, 95% confidence interval (CI): 1.08–1.64], after adjusting for age, sex, race, education and treatment group. This association differed between the active treatment group (OR: 1.57; 95% CI: 1.16–2.11) and the placebo group (OR: 1.17; 95% CI: 0.87–1.56), with a P for interaction = .049. Correspondingly, in the lowest FI quarter, antihypertensive treatment reduced dementia risk (OR: 0.19, 95% CI: 0.04–0.94), an effect not observed in higher FI quarters (interaction P = .058). Conclusion In patients with isolated systolic hypertension, frailty may serve as a risk factor for dementia, and elevated levels of frailty may attenuate the effectiveness of antihypertensive treatment in reducing dementia risk. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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