Polypharmacy, anticholinergic burden and inflammation in relation to accelerated biological ageing.
Background Polypharmacy is an emerging public health issue in ageing populations, linked to various adverse outcomes, yet its effect on biological ageing remains unclear. This study investigated the associations of polypharmacy and anticholinergic burden with biological ageing and evaluated the medi...
| Publicado en: | Age & Ageing Vol. 55; no. 2; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Feb2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=192513176&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 192513176 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2026 vid: 55 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 192513176 10.1093/ageing/afag048 ppf: 1 ppct: 11 formats: tig: atl: Polypharmacy, anticholinergic burden and inflammation in relation to accelerated biological ageing. aug: au: Wei, Kai Chen, Chun Sun, Shuimei Li, Dongmei Yang, Yanping Liu, Yan Zhang, Min Hu, Kui Chen, Qi affil: Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China Department of Pharmacy, Guizhou Branch of Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Guiyang, Guizhou, China Department of Pharmacy, Beth Israel Lahey Health Inc, Cambridge, Massachusetts, USA Department of Cardiovascular Surgery, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China su: Cross-sectional method Aging Anthropometry Old age Parasympathomimetic agents Pearson correlation (Statistics) Research funding Multiple regression analysis Polypharmacy Descriptive statistics Glucuronidase Inflammation Factor analysis Confidence intervals Cell receptors sug: subj: Cross-sectional method Aging Anthropometry Old age Parasympathomimetic agents Pearson correlation (Statistics) Research funding Multiple regression analysis Polypharmacy Descriptive statistics Glucuronidase Inflammation Factor analysis Confidence intervals Cell receptors keyword: aging anticholinergic agents anticholinergic burden biological biological ageing copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag048 inflammation inLanguage:en national health and nutrition examination survey older adult older people polypharmacy publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41804995/ aging anticholinergic agents anticholinergic burden biological biological ageing copyrightHolder:British Geriatrics Society copyrightYear:2026 https://dx.doi.org/10.1093/ageing/afag048 inflammation inLanguage:en national health and nutrition examination survey older adult older people polypharmacy publisher:Oxford University Press sameAs:https://pubmed.ncbi.nlm.nih.gov/41804995/ ab: Background Polypharmacy is an emerging public health issue in ageing populations, linked to various adverse outcomes, yet its effect on biological ageing remains unclear. This study investigated the associations of polypharmacy and anticholinergic burden with biological ageing and evaluated the mediating role of systemic inflammation. Methods We analysed data from the cross-sectional National Health and Nutrition Examination Survey (1999–2018), including US adults aged 65 years or older taking at least one prescription medication. Polypharmacy (5–9 drugs) and hyperpolypharmacy (≥10 drugs) were defined by concurrent use. Anticholinergic burden was assessed via the Anticholinergic Drug Scale (ADS). Biological ageing was measured using phenotypic age (PhenoAge), Klemera–Doubal biological age (KD-BioAge), anthropometric age (AnthroAge), frailty index, telomere length and α-Klotho. Inflammation was quantified using five blood cell–based indices. Weighted multiple linear regression and mediation analyses were performed. Results Among 10 556 older adults, 35.0% had polypharmacy and 5.5% hyperpolypharmacy. Both polypharmacy and anticholinergic burden were significantly associated with accelerated biological ageing per PhenoAge, KD-BioAge, AnthroAge and frailty index, adjusting for confounders. Systemic inflammation response index (SIRI) partially mediated the associations of polypharmacy and anticholinergic burden with PhenoAge (17.3%–26.9%, both P < .001) and KD-BioAge acceleration (9.8%–11.7%, both P < .001), and the ADS–SIRI pathway serially mediated the associations between polypharmacy and PhenoAge (3.1%, P = .003) or KD-BioAge acceleration (1.7%, P = .005). Conclusions Both polypharmacy and anticholinergic burden are associated with accelerated biological ageing, partly mediated by inflammation, including a potential serial pathway. The findings underscore the importance of deprescribing to reduce ageing-related risks. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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